Research status of ocular changes in beta-thalassemia major
10.3980/j.issn.1672-5123.2024.4.20
- VernacularTitle:重型β地中海贫血眼部变化的研究现状
- Author:
Yongcan WEI
1
;
Danna CHEN
1
;
Wenwen LI
1
;
Yani TONG
1
;
Guiling ZHAO
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
beta-thalassemia major;
ocular changes;
transfusion;
iron chelator;
oxidative stress
- From:
International Eye Science
2024;24(4):601-606
- CountryChina
- Language:Chinese
-
Abstract:
Beta-thalassemia major(β-TM)is an inherited disease caused by a defect in the synthesis of globin. The disease requires long-term blood transfusion and iron chelator treatment, which can cause various secondary changes in the body and eye tissues. Compared with normal peers, β-TM patients will show changes in the eye such as steeper corneal curvature, shallower anterior chamber, increased lens thickness, shorter axial length, and reduced tear secretion. At the same time, nutritional deficiencies and the use of iron chelator drugs will increase the risk of complicated cataract and retinal degeneration, thus affecting the quality of life of β-TM patients.This article combines relevant domestic and foreign literatures to explore and review the changes in the eye of β-TM patients, with a view to providing valuable insights for clinical practice.
