Application progress of proteomics in dry eye research
10.3980/j.issn.1672-5123.2024.4.17
- VernacularTitle:蛋白组学在干眼研究中的应用进展
- Author:
Ying YANG
1
;
Jiazhi ZHANG
1
;
Huijie JI
1
;
Weiping GAO
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
system biology;
proteomics;
dry eye;
biomarkers
- From:
International Eye Science
2024;24(4):585-588
- CountryChina
- Language:Chinese
-
Abstract:
The complex pathological mechanism of dry eye involves multiple pathways, such as immunity and inflammation, and requires an integral research program to control the whole picture. Various histological techniques can elucidate the complex physio-pathological state of organisms from a holistic and global perspective, thus providing more comprehensive biological information. Mass spectrometry can sensitively detect the changes of protein content in tear samples, providing convenience for proteomics research of dry eye. At present, proteomics has demonstrated its application in the identification of dry eye types, severity grading, and therapeutic effect evaluation. In addition, proteomics combined with metabolomics and microbiomics can more comprehensively explain the pathogenesis of dry eye. In the future, proteomics is expected to provide more powerful support for the precise diagnosis and treatment of dry eye, taking an advantage in targeted therapy.
