Research progress of related factors affecting poor response to wet age-related macular degeneration
10.3980/j.issn.1672-5123.2024.4.13
- VernacularTitle:影响湿性年龄相关性黄斑变性治疗应答不良的相关因素研究进展
- Author:
Haitao PAN
1
,
2
;
Ruizhuang LI
1
,
2
;
Qiuli ZHANG
1
,
2
;
Xuran CHEN
1
,
2
Author Information
1. Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China
2. Department of Ophthalmology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
wet age-related macular degeneration;
optical coherence tomography;
vascular endothelial growth factor;
poor response;
risk factors
- From:
International Eye Science
2024;24(4):567-571
- CountryChina
- Language:Chinese
-
Abstract:
Wet age-related macular degeneration(wARMD)emerges as a primary contributor to irreversible vision impairment in the aging demographic. In clinical practice, anti-vascular endothelial growth factor(VEGF)therapies exhibit pronounced success in managing wARMD. However, in the actual clinical application, there are significant individual differences in the prognosis of anti-VEGF drug therapy, and some patients show poor response to the treatment, which may be related to the morphological differences of retinal layers in macular area, genetics, systemic conditions and other factors. It will help develop a more rational and individualized treatment plan to judge the prognosis of patients according to their different clinical manifestations in advance, so as to reduce overtreatment and the risk of retinal damage. In recent years, most studies on treatment response mainly focus on fundus morphology, genetics and so on. In this study, the relevant factors affecting adverse response to wARMD were reviewed, aiming to provide with more accurate treatment and prognostic monitoring programs for clinicians.
