Case observation of viral keratitis caused by SARS-CoV-2

VernacularTitle:新型冠状病毒引起的病毒性角膜炎病例观察
Author: Mengzhen XIE ^{1
,

2} ; Hao ZHANG ^{1
,

2} ; Ke MA ^{1
,

2} ; Hongbo YIN ^{1
,

2} ; Lixiang WANG ^{1
,

2} ; Jing TANG ^{1
,

2}
Author Information

1. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
2. West China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Publication Type:Journal Article
Keywords: keratitis; COVID-19; SARS-CoV-2; Ganciclovir
From: International Eye Science 2024;24(4):495-499
CountryChina
Language:Chinese
Abstract: AIM: To report three cases of viral keratitis caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).METHODS: Slit lamp, intraocular pressure, corneal fluorescence staining, anterior segment photography, in vivo confocal microscopy(IVCM), and routine fundus screening were performed in the three confirmed patients. Treatment involved Ganciclovir, artificial tears and glucocorticoid eye drops.RESULTS: Three patients with SARS-CoV-2 keratitis(SCK)recovered well after standard treatment.CONCLUSION: SARS-CoV-2 keratitis typically presents as corneal subepithelial infiltration and can result in a decrease in corneal subepithelial nerve fiber density and an increase in dendritic cells(DC). Antiviral therapy in combination with glucocorticoid has proven to be effective.