Preparation and in vitro dissolution behaviors evaluation of silymarin phospholipid complex
10.12206/j.issn.2097-2024.202206051
- VernacularTitle:水飞蓟素磷脂复合物的制备及体外溶出行为评价
- Author:
Qiping ZENG
1
;
Jianqing LIU
2
;
Li'na YANG
3
;
Zhihong LIU
4
;
Hongtao SONG
4
Author Information
1. Department of Pharmacy, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, China.
2. School of Pharmacy, Quanzhou Medical College, Quanzhou 362000, China.
3. Department of Pharmacy, No.909 Hospital of Joint Logistic Support Force, Zhangzhou 363000, China.
4. Department of Pharmacy, No.900 Hospital of Joint Logistic Support Force, Fuzhou 350025, China.
- Keywords:
silymarin;
phospholipid complex;
solvent volatilization method;
central composite design and response surface methodology;
dissolution
- From:
Journal of Pharmaceutical Practice and Service
2024;42(3):101-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare silymarin phospholipids complex（SM-PC） and investigate its physicochemical properties. Methods On the basis of single-factor tests, the drug-lipid ratio, drug concentration and reaction temperature were selected as the factors of the central composite design and response surface methodology in the preparation of SM-PC by solvent volatilization, and the best process was optimized with the compound rate as the index. And its in vitro dissolution was measured. Results The optimum preparation technology of SM-PC was as follows: acetone was used as compound solvent, the concentration of SM was 8.0 mg/ml, the mass ratio of SM to phospholipid was 1∶1.8, the reaction temperature was 56 ℃ and the recombination rate was（95.15±1.55）% with deviation of less than 3%. The in vitro dissolution test showed that the dissolution of SM-PC was close to 90% in 60 min. The dissolution behavior of main component of silybin was similar to that of silymarin capsules（Legalon ®）, which was higher than SM-API. Conclusion SM-PC was successfully prepared by central composite design response surface method, which significantly improved the dissolution and laid a foundation for the study of subsequent preparations.
