Effects of occupational radiation exposure on peripheral blood lymphocyte count and cell cycle in logging workers
10.13491/j.issn.1004-714X.2024.01.005
- VernacularTitle:职业照射对测井工人外周血淋巴细胞数量和细胞周期的影响
- Author:
Weiguo LI
1
,
2
;
Gang GAO
3
;
Yan PAN
3
;
Hailiang LI
2
;
Jianlei RUAN
3
;
Chunnan PIAO
3
;
Jinghong FU
2
;
Jianxiang LIU
3
Author Information
1. Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088 China
2. School of Preventive Medicine (Institute of Radiation Medicine), Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan 250117 China.
3. Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Protection, Beijing 100088 China.
- Publication Type:OriginalArticles
- Keywords:
Logging worker;
Neutron-γ radiation;
Lymphocyte count;
Cell cycle;
Cyclin
- From:
Chinese Journal of Radiological Health
2024;33(1):28-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of prolonged low-dose neutron-γ radiation on peripheral blood lymphocytes of logging workers. Methods The health information of workers in a logging company was collected by on-site blood sample collection and questionnaire survey. Individual doses of γ and neutron radiation were recorded using LiF elements and CR-39, respectively. Lymphocyte count in peripheral blood was measured by blood cytometer. Cell cycle and cyclins were detected by flow cytometry. Results The annual dose of some logging workers exceeded 5 mSv. Lymphocyte counts showed a difference of 15% between the group exposed to the lowest annual dose of 0–1 mSv (mean: 2.45 × 109/L) and the group exposed to the highest annual dose of 5–25 mSv (mean: 2.08 × 109/L). In comparison to pre-shift workers, logging workers exhibited a G1-phase arrest in the lymphocyte cycle, along with increased expression of cyclins p21 and CDK2. Conclusion Prolonged exposure to low-dose neutron-γ radiation leads to reduced lymphocyte counts as well as changes in lymphocyte cycle and cyclin expression.
