Estimating the national burden of hospitalizations for influenza-associated severe acute respiratory infection in the Lao People’s Democratic Republic, 2016
10.5365/wpsar.2020.11.2.001
- Author:
Bouaphanh Khamphaphongphane
1
,
2
;
May Chiew
2
,
3
;
Joshua Mott
4
;
Sombandith Khamphanoulath
1
,
2
;
Viengphone Khanthamaly
2
,
5
;
Keooudomphone Vilivong
1
,
2
,
2
,
6
;
Thongchanh Sisouk
1
,
2
;
Leila Bell
7
;
Erica Dueger
8
,
9
,
10
;
Sheena Sullivan
11
;
Angela Daniella Iuliano
12
;
Reiko Tsuyuoka
2
,
3
;
Onechanh Keosavanh
1
,
2
Author Information
1. National Center for Laboratory and Epidemiology, Vientiane, Lao People&rsquo
2. s Democratic Republic
3. WHO Health Emergencies Programme, World Health Organization, Vientiane, Lao People&rsquo
4. Influenza Division, Thailand Regional Influenza Program, United States Centers for Disease Control and Prevention, Nonthaburi, Thailand
5. Influenza Division, United States Centers for Disease Control and Prevention, US Embassy, Vientiane, Lao People&rsquo
6. Influenza Division, United States Centers for Disease Control and Prevention, US Embassy, Vientiane, Lao People&rsquo
7. Health Emergency Information and Risk Assessment, WHO Health Emergencies Programme, World Health Organization, Regional Office for the Western Pacific, Manila, Philippines
8. Infectious Hazards Management, WHO Health Emergencies Programme, World Health Organization, Regional Office for the Western Pacific, Manila, Philippines
9. Influenza Division, United States Centers for Disease Control and Prevention, Atlanta, GA, United States of America
10. Sanofi Pasteur, Lyon, France
11. WHO Collaborating Centre for Reference and Research on Influenza, Royal Melbourne Hospital, Melbourne, and the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia
12. Influenza Division, United States Centers for Disease Control and Prevention, Atlanta, GA, United States of America
- Publication Type:Journal Article
- From:
Western Pacific Surveillance and Response
2021;12(2):19-27
- CountryWHO-WPRO
- Language:English
-
Abstract:
Objective: Estimates of the burden of influenza are needed to inform prevention and control activities for seasonal influenza, including to support the development of appropriate vaccination policies. We used sentinel surveillance data on severe acute respiratory infection (SARI) to estimate the burden of influenza-associated hospitalizations in the Lao People’s Democratic Republic.
Methods: Using methods developed by the World Health Organization, we combined data from hospital logbook reviews with epidemiological and virological data from influenza surveillance from 1 January to 31 December 2016 in defined catchment areas for two sentinel sites (Champasack and Luang Prabang provincial hospitals) to derive population-based estimates of influenza-associated SARI hospitalization rates. Hospitalization rates by age group were then applied to national age-specific population estimates using 2015 census data.
Results: We estimated the overall influenza-associated SARI hospitalization rate to be 48/100 000 population (95% confidence interval [CI]: 44–51) or 3097 admissions (95% CI: 2881–3313). SARI hospitalization rates were estimated to be as low as 40/100 000 population (95% CI: 37–43) and as high as 92/100 000 population (95% CI: 87–98) after accounting for SARI patient underascertainment in hospital logbooks. Influenza-associated SARI hospitalization rates were highest in children aged <5 years (219; 95% CI: 198–241) and persons aged >=65 years (106; 95% CI: 91–121).
Discussion: Our findings have identified age groups at higher risk for influenza-associated SARI hospitalization, which will support policy decisions for influenza prevention and control strategies, including for vaccination. Further work is needed to estimate the burdens of outpatient influenza and influenza in specific high-risk subpopulations.
- Full text:wpsar.2020.11.2.001 Khamphaphongphane FINAL.pdf
