Mitochondrial Quality Control Affects Diabetic Cardiomyopathy：Based on Theory of Qi Deficiency and Stagnation
10.13422/j.cnki.syfjx.20241194
- VernacularTitle:基于“虚气留滞”理论探讨线粒体质量控制对糖尿病心肌病的影响
- Author:
Aolin LI
1
;
Lu LIAN
2
;
Xinnong CHEN
3
;
Yingyu XIE
4
;
Zhipeng YAN
2
;
Wenhui CAI
2
;
QianQian ZHANG
2
;
Chi ZHANG
2
;
Junping ZHANG
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM），National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion，Tianjin 300381，China
2. Graduate School of Tianjin University of TCM，Tianjin 300193，China
3. Tianjin First Central Hospital，Tianjin 300190，China
4. College of TCM，Tianjin University of TCM，Tianjin 300193，China
- Publication Type:Journal Article
- Keywords:
diabetic cardiomyopathy;
mitochondrial quality control;
mitochondria;
Qi deficiency and stagnation;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(8):197-205
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing incidence of diabetes mellitus in recent years， cardiomyopathy caused by diabetes mellitus has aroused wide concern and this disease is characterized by high insidiousness and high mortality. The early pathological changes of diabetic cardiomyopathy （DCM） are mitochondrial structural disorders and loss of myocardial metabolic flexibility. The turbulence of mitochondrial quality control （MQC） is a key mechanism leading to the accumulation of damaged mitochondria and loss of myocardial metabolic flexibility， which， together with elevated levels of oxidative stress and inflammation， trigger changes in myocardial structure and function. Qi deficiency and stagnation is caused by the loss of healthy Qi， and the dysfunction of Qi transformation results in the accumulation of pathogenic Qi， which further triggers injuries. According to the theory of traditional Chinese medicine （TCM）， DCM is rooted in Qi deficiency of the heart， spleen， and kidney. The dysfunction of Qi transformation leads to the generation and lingering of turbidity， stasis， and toxin in the nutrient-blood and vessels， ultimately damaging the heart. Therefore， Qi deficiency and stagnation is the basic pathologic mechanism of DCM. Mitochondria， similar to Qi in substance and function， are one of the microscopic manifestations of Qi. The role of MQC is consistent with the defense function of Qi. In the case of MQC turbulence， mitochondrial structure and function are impaired. As a result， Qi deficiency gradually emerges and triggers pathological changes， which make it difficult to remove the stagnant pathogenic factor and aggravates the MQC turbulence. Ultimately， DCM occurs. Targeting MQC to treat DCM has become the focus of current research， and TCM has the advantages of acting on multiple targets and pathways. According to the pathogenesis of Qi deficiency and stagnation in DCM and the modern medical understanding of MQC， the treatment should follow the principles of invigorating healthy Qi， tonifying deficiency， and regulating Qi movement. This paper aims to provide ideas for formulating prescriptions and clinical references for the TCM treatment of DCM by targeting MQC.
