Effect of pre-pregnancy obesity on trimester-specific thyroid dysfunction
10.19428/j.cnki.sjpm.2024.23118
- VernacularTitle:孕前肥胖程度对妊娠期特异性甲状腺功能异常的影响
- Author:
Xin HE
1
;
Ping LIAO
1
;
Chazhen LIU
1
;
Jian QI
1
;
Qin YAN
1
;
Peiyun ZHU
1
;
Tong LIU
1
;
Wenjing WANG
1
;
Jiajie ZANG
1
Author Information
1. Shanghai Municipal Center for Disease Control and Prevention，Shanghai 200336，China
- Publication Type:Journal Article
- Keywords:
trimester;
thyroid dysfunction;
pre-pregnancy body mass index;
obesity
- From:
Shanghai Journal of Preventive Medicine
2024;36(1):78-83
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the risk of different levels of pre-pregnancy obesity on trimester-specific thyroid dysfunction. MethodsQuestionnaire information， blood samples， and urine samples from a 2017 pregnancy cohort study in Shanghai， China were collected. A total of 2 455 pregnant women were included in the analysis. Pre-pregnancy BMI was calculated based on the height and self-reported pre-pregnancy weight. Serum TSH， total thyroxine （TT4）， free thyroxine （FT4）， total triiodothyronine （TT3）， free triiodothyronine （FT3）， thyroid globulin antibody（TgAb）， and Thyroid peroxidase antibody （TPOAb） were measured using the electrochemiluminescence method. Urine iodine levels were measured using the acid digestion method. Levels of thyroid function indexes of pregnant women with different degrees of obesity during pre-pregnancy were compared， and trimester-specific thyroid dysfunction was evaluated according to the reference range of trimester-specific thyroid hormone established by this cohort. Multivariate logistic regressions analysis was used to assess the correlation between pre-pregnancy obesity and trimester-specific thyroid dysfunction. ResultsAs the degree of obesity increased， maternal levels of FT3 and TT3 gradually increased during pregnancy （P<0.001， P=0.001）， while FT4 levels gradually decreased （P=0.001）. Multivariate logistic regression analysis showed that compared with the normal weight group， pregnant women who were overweight or obesity before pregnancy had a significantly higher risk of hypothyroxinemia （OR=3.85， 95%CI： 2.08‒7.14， P<0.001） and high TT3 （OR=2.78， 95%CI： 1.45‒5.26， P=0.002） during pregnancy. ConclusionPre-pregnancy overweight or obesity can increase the risk of thyroid dysfunction during pregnancy.
