Clinical follow-up study of SARS-CoV-2 Omicron infection
10.19428/j.cnki.sjpm.2024.23006
- VernacularTitle:新型冠状病毒奥密克戎亚型感染临床随访研究
- Author:
Xiaoyu KANG
1
;
Lin ZHANG
2
;
Liangliang WANG
1
;
Rui YAN
1
;
Jiuping WANG
1
;
Zhangqian CHEN
1
Author Information
1. The First Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China
2. Central Medical District of Chinese PLA General Hospital, Beijing 100032, China
- Publication Type:Journal Article
- Keywords:
COVID-19;
Omicron variant;
negative viral conversion duration;
risk factor
- From:
Shanghai Journal of Preventive Medicine
2024;36(1):25-29
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical course and explore the risk factors for SARS-CoV-2 RNA negative conversion duration （NCD） in asymptomatic and mild-symptomatic patients infected with the SARS-CoV-2 Omicron variant. MethodsClinical data were collected from 244 confirmed cases of corona virus disease （COVID-19） with Omicron variant infection admitted to a temporal makeshift hospital in Shanghai from April 9， 2022 to May 20， 2022. Demographic and clinical data were analyzed， with a primary focus on the time of COVID-19 nucleic acid conversion. Univariate and multivariate Cox regression analysis were used to determine identify risk factors associated with NCD. ResultsThe median duration of negative RNA conversion was 9 days （ranged 7‒12 days）. The percentage of patients with positive nucleic acid results on the 5th， 7th， 10th， and 14th days after confirmed infection was 68.4%， 47.1%， 20.1%， and 5.7%， respectively. Kaplan-Meier curves indicated a median nucleic acid conversion time of 12 days （ranged 10‒14 days） for patients with hypertension， 9 days （ranged 7‒11 days） in patients without hypertension， and 11 days （ranged 9‒13 days） for patients aged ≥60 years， and 9 days （ranged 7‒11 days） for patients aged <60 years. Multivariate Cox regression analysis showed that only hypertension was an independent risk factor of NCD （RR=1.60； 95% CI： 1.03‒2.49， P=0.036）. ConclusionIn asymptomatic or mildly symptomatic patients infected with the Omicron variant， 20.1% patients continue to exhibit positive viral nucleic acid on the 10th days of infection. The independent risk factor associated with the conversion of SARS-CoV-2 nucleic acid to negative is hypertension.
