Mechanism of action and clinical research progress of iguratimod in connective tissue diseases
- VernacularTitle:艾拉莫德应用于结缔组织病的作用机制与临床研究进展
- Author:
Xiaorong YANG
1
,
2
;
Shuhong ZHOU
2
;
Lijiang GUO
1
,
2
;
Ying CHEN
2
;
Yingying JI
1
,
2
;
Lijie XU
1
Author Information
1. The First School of Clinical Medicine，Gansu University of Chinese Medicine，Lanzhou 730030，China
2. Dept. of Integrated Traditional Chinese and Western Medical Rheumatology & Immunology，Gansu Provincial Hospital，Lanzhou 730030，China
- Publication Type:Journal Article
- Keywords:
iguratimod;
connective tissue disease;
mechanism of action;
clinical application
- From:
China Pharmacy
2024;35(5):629-634
- CountryChina
- Language:Chinese
-
Abstract:
As a new type of immunosuppressant，iguratimod can mediate the anti-inflammatory signaling pathway by inhibiting the proliferation of inflammatory cells and reducing the release of inflammatory cytokines， and play the role of anti-inflammatory. It can affect the proliferation of immune cells and the expression of immune factors，reduce the production and deposition of immune complexes in the body，and play the role of immune regulation. It can regulate bone metabolism by mediating signaling pathways such as Wnt/β-catenin，Toll-like receptor 4/nuclear factor-κB and osteoprotegerin/nuclear factor-κB receptor activating factor ligand， and play a role in bone protection. It can inhibit pulmonary fibrosis by inhibiting the expression of transforming growth factor β1/ Smad2/3 signaling pathway，tumor necrosis factor-α，interleukin-1，interleukin-6，matrix metalloproteinase-9 and other inflammatory cytokines in lung tissue，and inhibiting the expression of collagen and fibronectin. Its efficacy and safety have been confirmed in the clinical application of rheumatoid arthritis and primary Sjogren syndrome and included in the diagnosis and treatment of the disease. It has also shown good efficacy in the clinical application of other connective tissue diseases such as systemic lupus erythematosus and ankylosing spondylitis，and no obvious safety risks have been found.
