Hematological Indicators of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Malaria-Infected Individuals
https://doi.org/10.47836/mjmhs.20.1.7
- Author:
Donia Zaid Hazem
1
;
Esraa Adel Mahmood
2
;
Anfal Saleh Mohammed
2
Author Information
1. Ibn Al-Atheer Teaching Hospital for Children, Mosul, Iraq
2. Alsalaam Teaching Hospital, Iraq
- Publication Type:Journal Article
- Keywords:
Antimalarial drugs, Hematological indicators, Hemolysis, Genetic condition, Malaria
- From:Malaysian Journal of Medicine and Health Sciences
2024;20(No.1):46-51
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Malaria, a life-threatening infectious disease caused by Plasmodium parasites, continues to be a major
global health concern, particularly in regions with high transmission rates. This retrospective cohort study aimed to
investigate the hematological indicators of G6PD deficiency in individuals infected with malaria. The study utilized
medical records and laboratory test results to analyze the hematological parameters and markers in individuals with
confirmed malaria and G6PD deficiency. Methods: Data were collected from the laboratory unit of Mosul Teaching
Hospitals in Ninevah Province, Iraq, from March 2021 to November 2022. The study population consisted of individuals diagnosed with malaria and with available G6PD deficiency test results. G6PD deficiency was determined
by measuring the G6PD enzyme activity in the patient’s blood. Hematological parameters, including complete blood
counts, platelet counts, and red blood cell indices, were recorded using a laboratory information system. Results: The
study population exhibited a relatively low prevalence of G6PD deficiency, with no significant differences observed
in age or gender distribution between individuals with and without G6PD deficiency. The distribution of malaria
types did not differ significantly between the two groups. However, patients with G6PD deficiency showed a significantly higher monocyte count, indicating a potential association between G6PD deficiency and altered monocyte
response during malaria infection. The clinical significance of this finding requires further investigation. Conclusion:
This study sheds light on the hematological indicators of G6PD deficiency in individuals infected with malaria. The
findings suggest a potential relationship between G6PD deficiency and altered monocyte response during malaria
infection.
- Full text:11.2024my1711.pdf
