Application of metagenomic next-generation sequencing in prevention and control of infection in solid organ transplantation
10.3969/j.issn.1674-7445.2023181
- VernacularTitle:宏基因组二代测序在实体器官移植感染防控中的应用
- Author:
Lin MAN
1
;
Xiaoshan LI
1
;
Wenjing WANG
2
;
Ting QIAN
1
;
Min XIONG
1
;
Hang YANG
1
;
Jingyu CHEN
1
;
Bo WU
1
Author Information
1. Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Department of Lung Transplant Center, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
2. .
- Publication Type:ReviewArticle
- Keywords:
Organ transplantation;
Metagenomic next-generation sequencing;
Immunosuppression;
Pulmonary infection;
Donor-derived infection;
Prevention and control of infection;
Pathogenic detection;
Polymerase chain reaction (PCR)
- From:
Organ Transplantation
2024;15(2):289-296
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation has become an effective treatment for multiple end-stage diseases. However, the recipients of organ transplantation need to take immunosuppressive drugs for a long time after operation, which leads to low immune function and relatively high incidence of bacterial, viral and fungal infections. Traditional microbial detection methods, such as pathogen culture, immunological detection and polymerase chain reaction, have been widely applied in infection detection, whereas these methods may cause problems, such as long detection time and presumed pathogens. Metagenomic next-generation sequencing has been widely adopted in infection prevention and control in organ transplantation in recent years due to high detection rate and comprehensive detection of pathogen spectrum. In this article, the application of metagenomic next-generation sequencing in the prevention and control of infection in solid organ transplantation was reviewed, aiming to provide reference for the diagnosis and treatment of transplantation-related infection.
