Latest research and prospect of CD47 in kidney transplantation
10.3969/j.issn.1674-7445.2024005
- VernacularTitle:CD47在肾移植中的最新研究与展望
- Author:
Yuxiang CHEN
1
;
Zhuocheng LI
1
;
Liang GAO
1
;
Xuyuan ZHU
1
;
Yu ZHANG
1
;
Tao LI
1
;
Hongtao JIANG
1
Author Information
1. Department of Transplantation, the Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China.
- Publication Type:ReviewArticle
- Keywords:
CD47;
Kidney transplantation;
Xenotransplantation;
Rejection;
Ischemia-reperfusion injury;
Immune cell;
Signal regulatory protein;
Thrombospondin
- From:
Organ Transplantation
2024;15(2):282-288
- CountryChina
- Language:Chinese
-
Abstract:
CD47 is a transmembrane protein widely expressed on cell surface, which is considered as a key molecule for immune escape. With an increasing number of related studies, the role of CD47 and its ligands in immunomodulatory effects has been gradually understood. Recent studies have investigated the role of CD47 in ischemia-reperfusion injury of allogenetic kidney transplantation, rejection and xenotransplantation. Nevertheless, the specific role and the key mechanism remain elusive. In this article, the structure and function of CD47, common CD47 ligands, the relationship between CD47 and kidney transplantation, and the application of CD47 in kidney transplantation were reviewed, the latest research progress of CD47 in kidney transplantation was summarized, and the limitations of current research and subsequent research direction were analyzed, aiming to provide reference for subsequent application of CD47 in allogeneic and kidney xenotransplantation.
