Present situation and progress of xenotransplantation at home and abroad

Xiaoyan Zhang; Guohui Wang; Shichao Han; Ruochen QI; Kepu Liu; Di Wei; Xiaojian Yang; Shuaijun MA; Kefeng Dou; Weijun Qin

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Present situation and progress of xenotransplantation at home and abroad

VernacularTitle:国内外异种器官移植的现状及进展
Author: Xiaoyan ZHANG ¹ ; Guohui WANG ¹ ; Shichao HAN ¹ ; Ruochen QI ¹ ; Kepu LIU ¹ ; Di WEI ¹ ; Xiaojian YANG ¹ ; Shuaijun MA ¹ ; Kefeng DOU ¹ ; Weijun QIN ¹
Author Information

1. Department of Urology, Xijing Hospital of Air Force Medical University, Xi’an 710032, China.
Publication Type:ReviewArticle
Keywords: Xenotransplantation; Genetically modified pig; Immunosuppressant; Non-human primate; Rejection; Inflammation; Coagulation disorder; Infection
From: Organ Transplantation 2024;15(2):276-281
CountryChina
Language:Chinese
Abstract: Organ shortage has become one of the major challenges hindering the development of organ transplantation. Xenotransplantation is one of the most valuable methods to resolve global organ shortage. In recent years, the development of genetic engineering technique and research and development of new immunosuppressant have provided novel theoretical basis for xenotransplantation. International scholars have successively carried out researches on xenotransplantation in genetically modified pigs to non-human primates or brain death recipients, making certain substantial progresses. However, most of the researches are still in the preclinical stage, far from clinical application. Therefore, according to the latest preclinical experimental research progress at home and abroad, the history of xenotransplantation, the development of gene modification technology, xenotransplantation rejection and immunosuppression regimens were reviewed, aiming to provide reference for subsequent research of xenotransplantation, promote clinical application of xenotransplantation and bring benefits to more patients with end-stage diseases.