Adenine phosphoribosyltransferase deficiency after kidney transplantation: a case report and literature review
10.3969/j.issn.1674-7445.2023182
- VernacularTitle:肾移植术后腺嘌呤磷酸核糖基转移酶缺乏症1例及文献复习
- Author:
Kun DONG
1
;
Ruiling SU
1
;
Junze CHEN
1
;
Guanmiao CHEN
2
;
Chunqiang DONG
1
Author Information
1. Department of Organ Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
2. .
- Publication Type:OriginalArticle
- Keywords:
Adenine phosphoribosyltransferase deficiency;
Kidney transplantation;
2,8-dihydroxyadenine;
Delayed graft function;
Graft dysfunction;
Genetic testing;
Hemodialysis;
Allopurinol
- From:
Organ Transplantation
2024;15(2):263-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the diagnosis and treatment experience of adenine phosphoribosyltransferase deficiency after kidney transplantation. Methods Clinical data of 1 patient with adenine phosphoribosyltransferase deficiency after kidney transplantation were retrospectively analyzed. Clinical characteristics, diagnosis, treatment and prognosis of adenine phosphoribosyltransferase deficiency were summarized by literature review. Results Renal biopsy showed that salt crystallization was found in most renal tubule lumen and positive results were observed under polarized light microscopy. After allopurinol, hemodialysis and anti-crystallization treatment, the graft function was gradually recovered. After postoperative 1-year follow-up, the patient's renal function was properly recovered. Conclusions Adenine phosphoribosyltransferase deficiency after kidney transplantation may lead to delayed graft function or graft dysfunction. Early detection, diagnosis and treatment may delay disease progression and improve renal function.
