Correlation between lung allocation score and early death risk of patients with idiopathic pulmonary fibrosis after lung transplantation
10.3969/j.issn.1674-7445.2023200
- VernacularTitle:肺源分配评分与特发性肺纤维化患者肺移植术后早期死亡风险的相关性分析
- Author:
Meirong GU
1
;
Minqiang LIU
2
;
Taoyin DAI
1
;
Sijia GU
1
;
Xiaoshan LI
2
;
Bo XU
1
;
Chunxiao HU
1
;
Jingyu CHEN
2
Author Information
1. Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Department of Anesthesiology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
2. .
- Publication Type:OriginalArticle
- Keywords:
Lung transplantation;
Lung allocation score;
Idiopathic pulmonary fibrosis;
Primary graft dysfunction;
Acute kidney injury;
Oxygenation index;
Bilirubin;
Central venous pressure
- From:
Organ Transplantation
2024;15(2):251-256
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the lung allocation score (LAS) and the risk of early death and complications in patients with idiopathic pulmonary fibrosis (IPF) after lung transplantation. Methods Clinical data of 275 patients with IPF were retrospectively analyzed. The correlation between LAS and the risk of early death in IPF patients after lung transplantation and the correlation between LAS and complications at postoperative 1 year was assessed by univariate and multivariate Cox regression analyses. Results Among 275 recipients, 62, 83, 95 and 108 cases died within postoperative 30, 90, 180 and 365 d, respectively. LAS was correlated with 30-, 90-, 180- and 365-d fatality of IPF patients (all P<0.05), whereas it was not correlated with the incidence of primary graft dysfunction (PGD) and acute kidney injury (AKI) at 365 d after lung transplantation (both P>0.05). Conclusions LAS is correlated with the risk of early death of IPF patients after lung transplantation. While, it is not correlated the incidence of PGD and AKI early after lung transplantation. Special attention should be paid to the effect of comprehensive factors upon PGD and AKI.
