Application of immune repertoire sequencing in solid organ transplantation
10.3969/j.issn.1674-7445.2023192
- VernacularTitle:免疫组库测序在实体器官移植中的应用
- Author:
Lifei LIANG
1
;
Tingting CHEN
2
;
Cheng YANG
2
,
3
Author Information
1. Department of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai 200032, China.
2. .
3. Department of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai 200032, China
- Publication Type:ExpertForum
- Keywords:
Immune repertoire;
T cell receptor;
B cell receptor;
Organ transplantation;
Rejection;
Infection;
Donor-derived cell-free DNA (dd-cfDNA);
T cell-mediated rejection (TCMR);
Antibody-mediated rejection (AMR);
Donor specific antibody(DSA);
Programmed cell death protein 1
- From:
Organ Transplantation
2024;15(2):207-213
- CountryChina
- Language:Chinese
-
Abstract:
Immune repertoire is defined as the sum of T cells and B cells, which possesses high diversity and enables immune system to respond to various antigen stimuli. With the development of sequencing technique, immune repertoire sequencing can be utilized to deeply understand the changes of lymphocyte clones when rejection occurs at the gene level, and also provide the possibility for the emergence of novel non-invasive diagnostic techniques based on immune repertoire sequencing. In recent years, more and more attempts have been made to apply immune repertoire sequencing in solid organ transplantation, especially in the fields of kidney transplantation, liver transplantation, heart transplantation and post-transplantation infection. In this article, research progresses on the application of immune repertoire sequencing in these fields were reviewed, and current status of immune repertoire sequencing in organ transplantation and its potential as a novel technique for early non-invasive diagnosis of rejection were summarized, aiming to provide reference for subsequent development and clinical application of this technique.
