Application of xenotransplantation in clinical practice
10.3969/j.issn.1674-7445.2023234
- VernacularTitle:走向临床的异种器官移植
- Author:
Shengkun SUN
1
;
Shujun YANG
2
;
Hao WEI
2
;
Haihong YANG
2
;
Jing LU
2
;
Jiang PENG
2
Author Information
1. Department of Urology, the Third Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100000, China.
2. .
- Publication Type:ExpertForum
- Keywords:
Xenotransplantation;
Organ transplantation;
Genetically modified pig;
Non-human primate;
Immunosuppression;
Physiological matching;
Cross species infection;
Ethic
- From:
Organ Transplantation
2024;15(2):200-206
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is the optimal treatment for end-stage organ failure. Nevertheless, organ shortage is a global problem, which limits further development of organ transplantation. Recent research shows that genetically modified pig may become a realistic alternative source of clinical organ transplantation donor. Xenotransplantation may serve as one of the effective measures to resolve the problem of organ shortage. Since 2021, 2 cases of living xenotransplantation and 6 cases of xenotransplantation in brain death recipients have been performed worldwide, and phase Ⅰ clinical trial of xenotransplantation has been launched, and the results have exceeded expectations. Therefore, in this article, recent clinical trial results of xenotransplantation in living and brain death recipients were retrospectively analyzed, and scientific, technical and ethical issues related to clinical research of xenotransplantation were illustrated, hoping to provide reference for clinical research of xenotransplantation in China and promote the development of xenotransplantation in clinical practice.
