Research progress in liver transplantation for colorectal liver metastasis
10.3969/j.issn.1674-7445.2023188
- VernacularTitle:肝移植治疗结直肠癌肝转移的研究进展
- Author:
Zhongjing HUANG
1
;
Ziyi WU
1
;
Junhua AI
1
Author Information
1. Department of General Surgery, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
- Publication Type:ExpertForum
- Keywords:
Unresectable colorectal cancer;
Liver metastasis;
Liver transplantation;
Molecular marker;
Shortage of donor;
Donor allocation;
Liver transplantation criteria;
Invasive biological behavior
- From:
Organ Transplantation
2024;15(2):185-190
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is one of the common malignant tumors in China. Studies have shown that more than 50% of patients with colorectal cancer will experience metastasis. After systematic treatment, patients with resectable colorectal cancer could obtain favorable 5-year survival rate. However, patients with unresectable colorectal liver metastasis constantly obtain poor prognosis. In spite of the development of medical treatment, patients with unresectable colorectal liver metastasis can be treated by multiple approaches, such as interventional therapy combined with targeted therapy and immunotherapy, clinical efficacy is relatively low. Hence, clinicians divert extensive attention to liver transplantation. Liver transplantation, as an emerging treatment in recent years, is expected to improve clinical prognosis of patients with unresectable colorectal liver metastasis. In this article, research progress in liver transplantation for patients with unresectable colorectal liver metastasis was reviewed, mainly including the historical overview, recent results, prognostic factors, adaptation criteria, relationship with systemic treatment, liver source shortage and donor allocation, aiming to provide reference for liver transplantation for patients with colorectal liver metastasis.
