Analysis of prognostic factors of extranodal NK/T-cell lymphoma treated with pegaspargase/L-asparaginase: a multicenter retrospective study.
10.3760/cma.j.issn.0253-2727.2023.08.005
- Author:
Zi Yuan SHEN
1
;
Xi Cheng CHEN
2
;
Hui Rong SHAN
3
;
Tao JIA
4
;
Wei Ying GU
5
;
Fei WANG
5
;
Qing Ling TENG
6
;
Ling WANG
6
;
Chun Ling WANG
7
;
Yu Ye SHI
7
;
Hao ZHANG
8
;
Yu Qing MIAO
9
;
Tai Gang ZHU
10
;
Chun Yan JI
11
;
Jing Jing YE
11
;
Ming Zhi ZHANG
12
;
Xu Dong ZHANG
12
;
Liang WANG
13
;
Kai Lin XU
2
;
Wei SANG
2
Author Information
1. Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China.
2. Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China.
3. Department of Hematology, Shuyang Hospital of Traditional Chinese Medicine, Suqian 223600, China.
4. Department of Hematology, the First People's Hospital of Lianyungang, Lianyungang 222002, China.
5. Department of Hematology, the First People's Hospital of Changzhou, Changzhou 213003, China.
6. Department of Hematology, Taian Central Hospital, Taian 271000, China.
7. Department of Hematology, Huai'an First People's Hospital, Huaian 223000, China.
8. Department of Hematology, the Affiliated Hospital of Jining Medical University, Jining 272000, China.
9. Department of Hematology, Yancheng First People's Hospital, Yancheng 224001, China.
10. Department of Hematology, the General Hospital of Wanbei Coal-Electric Group, Suzhou 234000, China.
11. Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, China.
12. Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
13. Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
Asparaginase;
Lymphoma, extranodal NK-T-cell;
Pegaspargase;
Prognosis
- MeSH:
Male;
Humans;
Middle Aged;
Asparaginase/therapeutic use*;
Prognosis;
Retrospective Studies;
Lymphoma, Extranodal NK-T-Cell/drug therapy*;
Antineoplastic Combined Chemotherapy Protocols/therapeutic use*;
Etoposide;
Cyclophosphamide;
Methotrexate/therapeutic use*;
DNA/therapeutic use*;
Treatment Outcome
- From:
Chinese Journal of Hematology
2023;44(8):642-648
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the prognostic factors of extracellular NK/T cell lymphoma (ENKTL) treated with pegaspargase/L-asparaginase. Methods: The clinical data of 656 ENKTL patients diagnosed at 11 medical centers in the Huaihai Lymphoma Working Group from March 2014 to April 2021 were retrospectively analyzed. The patients were randomly divided into two groups: a training set (460 cases) and a validation set (196 cases) at 7∶3, and the prognostic factors of the patients were analyzed. A prognostic scoring system was established, and the predictive performance of different models was compared. Results: Patients' median age was 46 (34, 57) years, with 456 males (69.5% ) and 561 nasal involvement (85.5% ). 203 patients (30.9% ) received a chemotherapy regimen based on L-asparaginase combined with anthracyclines, and the 5-year overall survival rate of patients treated with P-GEMOX regimen (pegaspargase+gemcitabine+oxaliplatin) was better than those treated with SMILE regimen (methotrexate+dexamethasone+cyclophosphamide+L-asparaginase+etoposide) (85.9% vs 63.8% ; P=0.004). The results of multivariate analysis showed that gender, CA stage, the Eastern Cooperative Oncology Group performance status (ECOG PS) score, HGB, and EB virus DNA were independent influencing factors for the prognosis of ENKTL patients (P<0.05). In this study, the predictive performance of the prognostic factors is superior to the international prognostic index, Korean prognostic index, and prognostic index of natural killer lymphoma. Conclusion: Gender, CA stage, ECOG PS score, HGB, and EB virus DNA are prognostic factors for ENKTL patients treated with pegaspargase/L-asparaginase.
