The prognostic significance of POD24 in 106 cases with splenic marginal lymphoma with bone marrow invasion.
10.3760/cma.j.issn.0253-2727.2020.03.008
- Author:
Rui LYU
1
;
Yu Ting YAN
1
;
Shu Hua YI
1
;
Ting Yu WANG
1
;
Shu Hui DENG
1
;
Wei LIU
1
;
Wen Yang HUANG
1
;
Gang AN
1
;
Wei Wei SUI
1
;
De Hui ZOU
1
;
Lu Gui QIU
1
;
Zeng Jun LI
1
Author Information
1. State Key Laboratory of Experimental Hematology, National Clinical Research Centre for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
- Publication Type:Journal Article
- Keywords:
Bone marrow invasion;
Clinical characteristics;
Overall survival;
POD24;
Splenic marginal zone lymphoma
- MeSH:
Adult;
Aged;
Bone Marrow;
Humans;
Lymphoma;
Middle Aged;
Prognosis;
Retrospective Studies;
Splenic Neoplasms
- From:
Chinese Journal of Hematology
2020;41(3):228-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of progression of disease within 24 months (POD24) on overall survival (OS) of splenic marginal lymphoma (SMZL) with bone marrow invasion, and to compare the clinical characteristics between POD24 SMZL with non-POD24 SMZL patients. Methods: The SMZL patients with bone marrow invasions were retrospectively analyzed between January 2002 and January 2017 treated in our institute, and the patients with sufficient follow-up time to judge POD24 were evaluated the clinical characteristics and prognosis, patients who died of non-progressive factors were excluded. Results: 106 patients were enrolled with a median age of 57 (25-79) years old. ①Clinical characteristics: All patients presented with bone marrow invasion and splenomegaly, 59.4% (63/106) with huge spleen, 14.8% (15/101) with hepatomegaly. Complex karyotype were found in 22.7% (18/79) patients; 13q deletion, 11q (ATM) deletion, 17p (TP53) deletion, and CEP12 abnormality patients presented with the percentage of 5.1% (4/78) , 1.3% (1/72) , 2.5% (2/80) , and 7.5% (4/53) , respectively.②Survival analysis: Univariate analysis showed that POD24, HGB less than 100 g/L and FISH detection of trisomy 12 were poor prognostic factors of OS. Multivariate analysis showed that only POD24 had independent prognostic significance[HR=20.116 (95%CI 2.226-181.820) , P=0.008]. ③Subgroup features: Patients with POD24 had significantly higher rates of mediastinal lymphadenopathy (63.6%vs 18.9%, P=0.005) and complex karyotype (50.0%vs 17.9%, P=0.024) than those without POD24. While the incidence of abdominal lymphadenopathy, anemia, thrombocytopenia, the lower albumin, and the increasing lactate dehydrogenase were higher in POD24 patients, but with no statistically difference. Conclusion: POD24 is an independent prognostic factor of the OS in SMZL. SMZL patients with mediastinal lymphadenopathy and complex karyotypes when diagnosed have a higher risk of POD24.
