Interstitial pneumonia in patients with diffuse large B-cell lymphoma receiving RCHOP and RCDOP regimens.
10.3760/cma.j.issn.0253-2727.2019.12.008
- Author:
Yan Na MENG
1
;
Shuo WANG
2
,
3
;
Qing SHI
2
,
3
;
Peng Peng XU
2
,
3
;
Shu CHENG
2
,
3
;
Li WANG
2
,
3
;
Wei Li ZHAO
2
,
3
Author Information
1. Xuzhou Center Hospital, Xuzhou 221009, China.
2. State Key Laboratory of Medical Genomics
3. Shanghai Institute of Hematology, Department of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- Publication Type:Journal Article
- Keywords:
Antineoplastic combined chemotherapy protocols;
Interstitial pneumonia;
Non-Hodgkin’s lymphoma
- MeSH:
Antineoplastic Combined Chemotherapy Protocols/adverse effects*;
Cyclophosphamide;
Doxorubicin;
Humans;
Lung Diseases, Interstitial/chemically induced*;
Lymphoma, Large B-Cell, Diffuse/drug therapy*;
Prednisone;
Retrospective Studies;
Rituximab;
Vincristine
- From:
Chinese Journal of Hematology
2019;40(12):1015-1020
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To identify the risk factors and clinical features associated with the interstitial pneumonia in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (RCHOP) or rituximab, cyclophosphamide, liposomal doxorubicin, vincristine and prednisone (RCDOP) regimens. Methods: A retrospective study was conducted in 836 patients with DLBCL admitted to the Department of Hematology at Ruijin Hospital from 2013 to 2018. Among them, 114 patients were treated with RCDOP regimen. Using the method of propensity score matching according to age, gender, IPI score of patients, 114 patients treated with RCHOP regimen were selected as controls. Clinical data, including comorbidities, gender, age, B symptoms, international prognostic index (IPI) score, disease stage, serum lactic dehydrogenase (LDH) and β(2) microglobulin (β(2)-MG) level were collected and the risk factors of interstitial pneumonia were further analyzed. Results: The interstitial pneumonia developed more frequently in RCDOP group than RCHOP group (28.95% vs 2.60%, P<0.01) . As the dose of liposomal doxorubicin elevated from 25-30 mg/m(2) to 35-40 mg/m(2), the incidence of interstitial pneumonia accordingly increased from 17.30% to 38.71% (P<0.05) . By multivariate analysis, disease stage was an independent factor of interstitial pneumonitis. Conclusions: Front line regimens containing liposomal doxorubicin in DLBCL patients link to a higher incidence of dose-dependent interstitial pneumonia. Prevention and surveillance should be emphasized in future studies.
