Effect of nilotinib on pregnancy outcome in female patients with chronic myeloid leukemia.
10.3760/cma.j.issn.0253-2727.2019.12.003
- Author:
Hui Fang ZHAO
1
;
Yong Ping SONG
1
;
Zhen LI
1
;
Jian ZHOU
1
;
Feng Kuan YU
1
;
Rui Rui GUI
1
;
Ying Ling ZU
1
;
Xu Dong WEI
1
;
Yanli ZHANG
1
Author Information
1. Department of Hematology, Henan Cancer Hospital, the Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450008, China.
- Publication Type:Journal Article
- Keywords:
Leukemia, myeloid, chronic;
Nilotinib;
Pregnancy
- MeSH:
Adult;
Child, Preschool;
Female;
Humans;
Infant;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy*;
Male;
Pregnancy;
Pregnancy Outcome;
Pyrimidines/therapeutic use*;
Retrospective Studies
- From:
Chinese Journal of Hematology
2019;40(12):986-989
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the pregnancy outcome among patients with chronic myeloid leukemia (CML) treated with Nilotinib (NIL) . Methods: Clinical data of pregnancy delivery in CML patients treated with NIL from March 2015 to January 2019 were retrospectively collected. Results: A total of 11 patients were recruited with median pregnancy age 28 (25-40) years. The median duration of NIL treatment before pregnancy was 34 (3-48) months. There were 12 pregnancies, included 2 planned ones and 10 (83.3%) unplanned. In the 10 unplanned patients, 9 (90.0%) received NIL 600 mg/d. The median exposure time were 4 (4-7) weeks. In eight patients with delivery outcomes, 5 cases had well-developed babies, 2 had spontaneous abortion and 1 case with an baby of syndactyly deformity, whose mother was exposed to NIL 600 mg/d for 7 weeks in the early trimester of pregnancy. Seven infants were 4 boys and 3 girls with the median height at birth 50 (41-54) cm and median weight 3.2 (3.0-4.6) kg. They all grew with a normal pattern and well developed. Now the median age is 19 (4-41) months. The disease status during 12 pregnancies included 3 cases in CMR, 2 cases in MR(4.0), 3 cases in MMR, 4 cases not acquiring MMR. The median time of drug discontinuation was 35 (15-36) weeks during pregnancy. No patient lost CHR during this period. Conclusions: Female CML patients exposed to NIL 600 mg/d for 4 weeks in early pregnancy can give birth to normal babies, but there is still a risk of spontaneous abortion and congenital malformations.
