The prognosis value of comprehensive geriatric assessment in elder patients with acute myeloid leukemia in a single center.
10.3760/cma.j.issn.0253-2727.2019.03.007
- Author:
Jie Fei BAI
1
;
Di MEI
;
Hui Xiu HAN
;
Shuai ZHANG
;
Ru FENG
;
Jiang Tao LI
;
Ting WANG
;
Chun Li ZHANG
;
Shang Yong NING
;
Hui LIU
Author Information
1. Department of Hematology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
Acute myeloid leukemia;
Comprehensive geriatric assessment;
Eldly patients;
Prognosis
- MeSH:
Aged;
Comorbidity;
Geriatric Assessment;
Humans;
Leukemia, Myeloid, Acute;
Prognosis
- From:
Chinese Journal of Hematology
2019;40(3):200-203
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the prognostic significance of comprehensive geriatric assessment (CGA) in Chinese elderly acute myeloid leukemia (AML) patients. Methods: 73 AML patients over the age of 60 were enrolled. CGA stratification included the following 3 instrument assessment: activity of daily living (ADL) ; instrumental activity of daily living (IADL) ; comorbidity score according to the Modified cumulative illness rating score for geriatrics (MCIRS-G) . According to CGA and age, the enrolled patients were grouped into 'fit', 'unfit' and 'frail' categories. Results: The median age of 73 elderly AML patients were 75 years old. According to CGA, 37 (50.1%) patients were classified as 'fit', 14 (19.2%) as 'unfit', and 22 (30.7%) as 'frail'. 33 (89.2%) patients in fit group received induction chemotherapy, or demethylation treatment, as 8 (57.9%) in unfit, 10 (45.5%) in frail. The overall response rate was 68.7%、62.5%, 75.0% in fit, unfit, and frail group, respectively (χ(2)=0.615, P=0.769) .The early mortality (8 weeks) in three groups were different: 5.4%, 7.1%, 27.3%, respectively (P<0.05) . The 1-year overall survival in the 'fit', 'unfit' and 'frail' groups was 64.9%, 28.6% and 22.7%, respectively (P<0.05) . The CGA score, age, ECOG score, WHO classification (2016) were the prognostic factors of AML patients. Conclusion: CGA can be used to determine the prognosis of elderly AML patients.
