Clinical features and risk factors of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.
10.3760/cma.j.issn.0253-2727.2019.03.004
- Author:
Qian WU
1
;
Fang ZHOU
;
Ning Xia SONG
;
Xi Min LIU
;
Zhe YU
;
Xiao Chen SONG
;
Xin LI
;
Hong ZHANG
Author Information
1. Department of Hematology, PLA 960 Hospital, Jinan 250031, China.
- Publication Type:Journal Article
- Keywords:
Graft verus host disease;
Hemorrhagic cystitis;
hematopoietic stem cell transplantation
- MeSH:
Adolescent;
Adult;
Child;
Child, Preschool;
Cystitis/etiology*;
Female;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Humans;
Male;
Middle Aged;
Retrospective Studies;
Risk Factors;
Young Adult
- From:
Chinese Journal of Hematology
2019;40(3):187-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relative risk factors, clinical intervention and prognosis of hemorrhagic cystitis (HC) in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT) . Methods: From January 1 2010 to May 31 2017, 425 patients with allo-HSCT received a retrospective analysis. Results: ①Among the 425 patients, 262 were male and 163 were female. The median age was 26 (2-56) years old. There were 138 cases of acute myeloid leukemia (AML) , 96 cases of acute lymphoblastic leukemia (ALL) , 29 cases of myelodysplastic syndrome (MDS) , 98 cases of severe aplastic anemia (SAA) and 64 cases of chronic myeloid leukemia (CML) . 221 cases of sibling match transplantation, 89 cases of unrelated donor transplantation and 115 cases of haplotype transplantation. ②108 patients (25.41%) developed HC, with the median time of onset of 32 (3-243) days and the median duration of 20 (3-93) days; 33 cases (30.56%) were grade Ⅰ, 49 cases of grade Ⅱ (45.36%) , 21 cases (19.44%) of grade Ⅲ, and 5 cases (4.63%) of grade Ⅳ. ③103 cases of HC were cured, 5 patients were ineffective, 12 patients died and died of transplantation related complications (infection, recurrence, severe acute GVHD, secondary implant failure) . ④Univariate analysis showed that age < 30, type of transplantation, CMV and acute GVHD were associated with the occurrence of HC after allo-HSCT. Multivariate analysis showed that acute GVHD was an independent risk factor for HC after allo-HSCT. Conclusion: Prognosis of HC after allo-HSCT was better after timely treatment.
