The usage of comprehensive geriatric assessment in elderly patients with acute myeloid leukemia: a multicenter, prospective study.
10.3760/cma.j.issn.0253-2727.2019.01.007
- VernacularTitle:综合老年学评估在老年急性髓系白血病患者中应用的多中心、前瞻性研究
- Author:
Qi WU
1
;
Rong FU
2
;
Ming Feng ZHAO
3
;
Yi Gai MA
4
;
Hao JIANG
5
;
Liang ding HU
6
;
Yu JING
7
;
Hui LIU
8
;
Li Ru WANG
9
;
Li SU
10
;
Yong Qing ZHANG
11
;
Chun Lin ZHOU
12
;
Yan ZHANG
13
;
Han Yun REN
14
;
Bin JIANG
15
;
He Bing ZHOU
16
;
Lin KANG
1
;
Lu ZHANG
1
;
Dao Bin ZHOU
1
;
Jian LI
1
Author Information
1. Peking Union Medical College Hospital, Beijing 100730, China.
2. General Hospital, Tianjin Medical University, Tianjin 300052, China.
3. Tianjin First Central Hospital, Tianjin 300192, China.
4. China-Japan Friendship Hospital, Beijing 100029, China.
5. People's Hospital, Peking University, Beijing 100044, China.
6. 307 PLA Hospital, Beijing 100071, China.
7. Chinese PLA General Hospital, Beijing 100853, China.
8. Beijing Hospital, Beijing 100730, China.
9. Fuxing Hospital, Capital Medical University, Beijing 100038, China.
10. Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
11. the 309th Hospital of Chinese PLA, Beijing 100091, China.
12. Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
13. Beijing Longfu Hospital, Beijing 100010, China.
14. Peking University First Hospital, Beijing 100034, China.
15. Peking University International Hospital, Beijing 102206, China.
16. Beijing Luhe Hospital, Capital Medical Unversity, Beijing 101100, China.
- Publication Type:Multicenter Study
- Keywords:
Comprehensive geriatric assessment;
Elderly;
Leukemia, myeloid, acute
- MeSH:
Activities of Daily Living;
Aged;
China;
Geriatric Assessment;
Humans;
Leukemia, Myeloid, Acute;
Prospective Studies
- From:
Chinese Journal of Hematology
2019;40(1):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the feasibility and potential value of comprehensive geriatric assessment (CGA) in elderly (≥60 years) patients with newly diagnosed acute myeloid leukemia (AML) in China. Methods: The CGA results of 83 newly diagnosed AML (non-APL) patients from 16 hospitals in Beijing and Tianjin between March 2016 and December 2017 were prospectively collected and analyzed. The clinical data, treatment and follow-up information were also collected. Results: Of 83 newly diagnosed elderly AML patients, 81 patients (97.6%) completed all designated CGA assessment. The median number of impaired scales of the CGA assessment in the studied population was 2(0-6). Sixteen patients (19.3%) showed no impairments according to the geriatric assessment scales implem ented by this study. The distributions of impaired scales were as follows: impairment in ADL, 55.4%; IADL impairment, 42.2%; MNA-SF impairment, 48.2%; cognitive impairment, 15.7%; GDS impairment, 31.7%; HCT-CI impairment, 19.5%, respectively. In patients with "good" ECOG (n=46), the proportion of impairment for each CGA scale ranged from 6.5% to 37.0% and 32 patients (68.9%) had at least one impaired CGA scale. Survival analysis showed that the number of impaired scales of the CGA was significantly correlated with median overall survival (P=0.050). Conclusions: CGA was a tool with feasibility for the comprehensive evaluation in elderly AML patients in China. Combined with age and ECOG, CGA may be more comprehensive in assessing patients' physical condition.
