Age-related clinical characteristics and prognosis in non-senile adults with acute myeloid leukemia.
10.3760/cma.j.issn.0253-2727.2018.12.001
- Author:
Xue Lin DOU
1
;
Ting ZHAO
;
Lan Ping XU
;
Xiao Hui ZHANG
;
Yu WANG
;
Huan CHEN
;
Yu hong CHEN
;
Chen Hua YAN
;
Wei HAN
;
Feng Rong WANG
;
Jing Zhi WANG
;
Yao CHEN
;
Hao JIANG
;
Hong Hu ZHU
;
Jin Song JIA
;
Jing WANG
;
Bin JIANG
;
De Bing WANG
;
Kai Yan LIU
;
Xiao Jun HUANG
;
Qian JIANG
Author Information
1. Peking University People's Hospital, Peking University Institute of Hematology, Beijing 100044, China.
- Publication Type:Journal Article
- Keywords:
Adult;
Age;
Clinical characteristics;
Leukemia, myeloid, acute;
Prognosis
- MeSH:
Adolescent;
Adult;
Aged;
Female;
Humans;
Leukemia, Myeloid, Acute;
Male;
Middle Aged;
Mutation;
Nucleophosmin;
Prognosis;
Remission Induction;
Retrospective Studies;
Young Adult;
fms-Like Tyrosine Kinase 3
- From:
Chinese Journal of Hematology
2018;39(12):969-976
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore age-related clinical characteristics, early responses and outcomes in non-senile adults with de novo acute myeloid leukemia (AML). Methods: Data of consecutive cases of 18-65 years adults with de novo AML (non-acute promyelocytic leukemia) were reviewed retrospectively. Clinical characteristics at diagnosis, early responses and outcomes across different age groups of patients were analyzed. Results: 1 097 patients were enrolled. 591 (53.9%) were male. Median age was 42 years. Increasing age was significantly associated with decreasing WBC count (P=0.003), increasing PLT count (P=0.034), lower blast proportions in bone marrow (P=0.021). The incidence of NPM1(+)/FLT3-ITD(-) increased with age (P<0.001). Multivariate analyses showed that increasing age was associated with low probabilities of achieving morphologic leukemia free state (MLFS) (P=0.053) and complete remission (CR) (P=0.004) and poor overall survival (OS) (P=0.070) in the whole patients population. However, increasing age was not associated with low MLFS rate and poor OS, except low CR rate (P=0.075) in those receiving standard induction regimen instead of low-intensity regimen. Conclusions: There were significant differences on clinical characteristics, cytogenetics and molecular genetics across different age groups in non-senile adults with de novo AML. In the patients receiving standard induction regimen, age was not associated with MLFS rate and OS.
