Clinical analysis of hemorrhagic cystitis in children and adolescents with hematological diseases post haplo-hematopoietic stem cell transplantation.
10.3760/cma.j.issn.0253-2727.2018.10.009
- Author:
Yun Xia XIE
1
;
Yu WANG
;
Xiao Jun HUANG
;
Lan Ping XU
;
Xiao Hui ZHANG
;
Kai Yan LIU
;
Chen Hua YAN
;
Feng Rong WANG
;
Yu Qian SUN
;
Jun KONG
;
Yan Qun GAO
;
Hong Yu SHI
;
Duo Ping LIU
;
Yi Fei CHENG
Author Information
1. Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.
- Publication Type:Journal Article
- Keywords:
Haplo-hematopoietic stem cell transplantation;
Hemorrhagic cystitis;
Risk factors
- MeSH:
Adolescent;
Child;
Child, Preschool;
Cystitis;
Female;
Hematologic Diseases;
Hematopoietic Stem Cell Transplantation;
Humans;
Incidence;
Male;
Retrospective Studies;
Risk Factors
- From:
Chinese Journal of Hematology
2018;39(10):833-838
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the incidence and clinical features to probe the risk factors of hemorrhagic cystitis (HC) in children and adolescents with hematological diseases post haplo-hematopoietic stem cell transplantation (haplo-HSCT) . Methods: Medical records of 62 children and 27 adolescents with hematological diseases treated with haplo-HSCT between 2015 and 2016 were analyzed. Results: Of 89 cases (56 boys and 33 girls) , 44 patients were diagnosed with ALL, 33 AML, 3 AHL and 9 MDS. HC occurred in 32 of the 89 patients with an incidence of 36%, including 6 with grade Ⅰ, 16 with grade Ⅱ, 8 with grade Ⅲ, 2 with grade Ⅳ HC, respectively. The median time of HC onset was 25 days (range 2-55 days) after haplo-HSCT with the median duration as 19 days (range 3-95 days) , all of them were cured. The incidence of HC was lower in the group of children than that in the group of adolescents (27.4% vs 55.6%, χ(2)=6.466, P<0.05) , and the incidence of HC was higher in the group of patients who were ≥5 years old than that in the group of patients who were <5 years old (0 vs 34%, χ(2)=4.043, P<0.05) . Conclusion: HC is one of common complications in children and adolescents with hematological diseases post haplo-HSCT, older age was associated with increased mortality.
