Clinical significance of minimal residual disease in patients with Ph-negative precursor B-acute lymphoblastic leukemia.
10.3760/cma.j.issn.0253-2727.2018.09.004
- Author:
Kai Qq LIU
1
;
Hui WEI
;
Dong LIN
;
Ying WANG
;
Chun Lin ZHOU
;
Bing Cheng LIU
;
Xing Li ZHAO
;
Yan LI
;
Hui Jun WANG
;
Cheng Wen LI
;
Qing Hua LI
;
Ben Fa GONG
;
Yun Tao LIU
;
Xiao Yuan GONG
;
Ying Chang MI
;
Jian Xiang MI
;
Jianxiang WANG
Author Information
1. Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.
- Publication Type:Journal Article
- Keywords:
Flow Cytometry;
Leukemia, lymphoblastic;
Minimal residual disease;
Prognosis
- MeSH:
Flow Cytometry;
Humans;
Neoplasm, Residual;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Prognosis;
Recurrence
- From:
Chinese Journal of Hematology
2018;39(9):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the predictive value of minimal residual disease (MRD) level in Ph-negative precursor B-acute lymphoblastic leukemia (ALL) patients. Methods: De novo 193 Ph-negative B-ALL patients from Sep 2010 to Nov 2017 were involved in the study. The patients' MRD evaluation which can be performed by multiparametric flow cytometry (MFC) after 1 month, 3-month, 6-month treatment. Relapse free survival (RFS) and overall survival (OS) were compared in patients with different MRD level. Results: The median follow-up was 22 months. All patients was evaluated at 497 MRD level. Patients who reach the good MRD level at 1 month (<0.1% or ≥0.1%), 3-month (negative or positive), 6-month (negative or positive) had a significantly higher probability of estimated RFS (74.5% vs 29.9%; 75.6% vs 29.7%; 74.6% vs 11.6%) and of estimated OS (67.5% vs 30.3%; 71.6% vs 27.8%; 74.0% vs 15.7%). Patients who reach the MRD negative at all 3 times had a significantly higher probability of estimated RFS (80.5% vs 30.5%) and better estimated OS (77.1% vs 29.4%) compared to patients with at least MRD failure in one time (P<0.001). Multivariable analysis showed MRD level at 3-month was an independent prognostic factor for DFS and OS. Conclusion: MRD is an important prognosis factor for Ph-negative B- ALL patients.
