The value of serum heavy/light chain immunoassay to assess therapeutic response in patients with multiple myeloma.
10.3760/cma.j.issn.0253-2727.2018.04.004
- VernacularTitle:重轻链检测在多发性骨髓瘤疗效评价中的意义
- Author:
Xiao Chen YU
;
Wei SU
;
Jun Ling ZHUANG
1
Author Information
1. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
Immunoglobulin heavy chains;
Immunoglobulin light chains;
Multiple myeloma;
Treatment outcome
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Female;
Humans;
Immunoassay;
Immunoglobulin Heavy Chains;
Immunoglobulin Light Chains;
Male;
Middle Aged;
Multiple Myeloma;
Retrospective Studies
- From:
Chinese Journal of Hematology
2018;39(4):281-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the value of immunoglobulin heavy/light chain (HLC) immunoassay on therapeutic response in patients with multiple myeloma(MM). Methods: A total of 45 newly diagnosed MM patients were retrospectively enrolled in Peking Union Medical College Hospital from 2013 to 2016, whose 115 serum samples were consecutively collected. HLC was tested to evaluate response and compare with other methods for M protein detection. Results: ①There were 30 males and 15 females in total of whom the monoclonal immunoglobulin was IgG in 27 (IgGκ∶IgGλ 12∶15) and IgA (IgAκ∶IgAλ 9∶9) in 18. The arerage age of the studied population was 59 (range 43-80) . ② In 34 patients with serum sample at diagnosis, 32 (94.1%) had abnormal HLC ratio (rHLC) while 2 patients with IgG had normal rHLC. The percentages of abnormal rHLC was 81.8% (18/22) at partial response、50.0%(9/18) at very good complete response and 16.0%(4/25) at complete response. ③In 25 patients reaching CR, there were 13 with IgG and 12 with IgA. 4 patients equally split of IgG and IgA had abnormal rHLC at complete response. ④By monitoring the rHLC of some patients consecutively, we found that the remission of rHLC was to some extent behind the remission of SPE and IEF, or even rFLC. Conclusion: Immunoglobulin HLC detection is one feasible method for minimal residual disease detection.
