Correlation between airway remodeling and lung function in adult-onset eosinophilic asthma

Tingting Han; Zhiran Liang; Meijuan Shi; Liyu HE; Chenwang Jin; Youming Guo

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Correlation between airway remodeling and lung function in adult-onset eosinophilic asthma

VernacularTitle:成人起病型嗜酸性哮喘患者的气道重塑与肺功能的相关性分析
Author: Tingting HAN ¹ ; Zhiran LIANG ² ; Meijuan SHI ³ ; Liyu HE ¹ ; Chenwang JIN ¹ ; Youming GUO ¹
Author Information

1. Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060
3. Department of Medical Imaging, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
Publication Type:Journal Article
Keywords: asthma; eosinophil; quantitative CT; airway remodeling
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(5):730-734
CountryChina
Language:Chinese
Abstract: 【Objective】 To investigate the airway parameters of adult-onset eosinophilic asthma （EA） and analyze the correlation between airway remodeling and lung function by quantitative CT. 【Methods】 From March 2015 to November 2016， totally 94 subjects from the “FACT-Digital Lung” Multi-research Center were divided into three groups： 30 normal subjects， 33 EA patients and 31 non-eosinophilic asthma （NEA） patients. We measured and recorded the bronchial parameters of RB1， LB1+2， RB10， and LB10， and small airway disease parameters. The indicators for quantitative evaluation of bronchial parameters include lumen area （LA）， wall thickness （WT）， wall area （WA）， and wall area percentage （WA%）. The parameters for the quantitative assessment of small airway disease included the percentage of inspiratory voxels below -950HU （IN-950）， the mean lung density （MLDin）， and the whole volume of the lung in inspiration （Vin）. Pearson or Spearman rank correlation analysis was used to evaluate the correlation between these parameters and lung function. 【Results】 The differences in LA/BSA， WT/√BSA， and WA/BSA between the three groups were statistically significant （P<0.05）. FEV1% had a significant correlation with IN-950 and MLDin （P<0.01）. FEV1/FVC had a significant correlation with Vin， IN-950， and MLDin （P<0.01）. EOS counts were positively related to IN-950 （r=0.343， P=0.011）， while EOS had a negative correlation with FEV1% （r=－0.343， P=0.015）. 【Conclusion】 With the increase of eosinophils counts in peripheral blood， the airway's stenosis in asthma patients gradually increased， and the extent of airflow limitation steadily increased. The IN-950 may be a sensitive imaging biomarker for evaluating the small airway disease in adult-onset eosinophilic asthma patients.