Association between the entorhinal cortex and cognitive function in traumatic brain injury based on structural magnetic resonance imaging

Yitong Bian; Miaomiao Chen; Hua LI; Xianjun LI; Yao GE; Suhang Shang; Jian Yang

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Association between the entorhinal cortex and cognitive function in traumatic brain injury based on structural magnetic resonance imaging

VernacularTitle:基于结构磁共振探讨创伤性脑损伤后内嗅皮层改变与认知功能的关系
Author: Yitong BIAN ¹ ; Miaomiao CHEN ^{1
,

2} ; Hua LI ³ ; Xianjun LI ¹ ; Yao GE ¹ ; Suhang SHANG ⁴ ; Jian YANG ¹
Author Information

1. Department of Radiology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Department of Radiology, Yulin Second Hospital, Yulin 719000
3. Department of Radiology, Yulin Second Hospital, Yulin 719000
4. Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Publication Type:Journal Article
Keywords: traumatic brain injury; entorhinal cortex; cognitive function; structural magnetic resonance imaging
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2021;42(6):875-879
CountryChina
Language:Chinese
Abstract: 【Objective】 To explore the relationship between changes in the entorhinal cortex （EC） of traumatic brain injury （TBI） and cognitive function based on structural magnetic resonance imaging. 【Methods】 MRI was performed in 26 patients with clinically confirmed TBI after admission， and the Mini-mental State Examination （MMSE） was followed up 6 months later. The TBI patients were classified as mild TBI and moderate to severe TBI according to the post-traumatic Glasgow coma scale （GCS）. We compared the differences in age， gender， education level， hypertension， diabetes， TBI operation history， and follow-up MMSE between the two groups. Then the morphology， surface area， volume and thickness of the patient’s EC were evaluated using the visual score and Freesurfer software， and finally the correlation between EC parameters and MMSE was analyzed. 【Results】 The study included 12 cases of mild TBI and 14 cases of moderate to severe TBI. There were no statistical differences in age， gender， years of education， hypertension， diabetes or TBI operation history. However， the two groups differed significantly in follow-up MMSE. Visual evaluation showed statistical difference in the left EC scores. Structural MRI showed that the volume and thickness of left EC were statistically different between the two groups. The correlation analysis showed that there was a positive correlation between the thickness of left EC and MMSE （r=0.430， P<0.05）. 【Conclusion】 Entorhinal cortex atrophy after TBI is related to the severity of trauma， and it can reflect the long-term cognitive level of patients， which can be used as a noninvasive and reliable imaging marker for evaluating cognitive impairment after TBI.