A Case of Cerebral Aspergillosis in a Patients with Rheumatoid Arthritis.
- Author:
Tae Kun LEE
1
;
Jae Hoon CHOI
;
Cheul Woong CHOI
;
Sang Yong LEE
;
Jun Hee LEE
;
Joung Wook LEE
;
Sang Soo KIM
;
Sung Il KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea. ksimd@pusan.ac.kr
- Publication Type:Case Report
- Keywords:
Rheumatoid arthritis;
Invasive Aspergillus;
Central nervous system
- MeSH:
Arthritis, Rheumatoid*;
Aspergillosis*;
Aspergillus;
Basal Ganglia;
Biopsy;
Brain;
Central Nervous System;
Dizziness;
Dysarthria;
Female;
Humans;
Hydroxychloroquine;
Internal Capsule;
Magnetic Resonance Imaging;
Mesencephalon;
Methotrexate;
Middle Aged;
Physical Examination;
Pons;
Pupil;
Reflex;
Sleep Stages;
Thalamus
- From:The Journal of the Korean Rheumatism Association
2003;10(4):438-441
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of aspergillosis of the central nervous system in patient with rheumatoid arthritis (RA). A 46-year-old woman with 20-year history of RA and on treatment with corticosteroid, hydroxychloroquine and methotrexate, was admitted because of drowsiness, dizziness and dysarthria. On admission, physical examination and laboratory data showed, among other findings, disappearance of pupil reflex, positive Babinski and Chaddock reflex. Magnetic resonance imaging (MRI) of brain showed multiple high signal intensity lesion on medulla, pons, midbrain, basal ganglia, internal capsule, thalamus and hypothalmus. Stereotactic brain biopsy was performed and biopsy specimen revealed an invasive Aspergillus.
