Correlation between serum trace elements and blood pressure in healthy people and patients with hypertension
- VernacularTitle:健康人群和高血压患者血清微量元素与血压的相关性分析
- Author:
Tuo HAN
1
;
Hong GONG
2
;
Yang XU
3
;
Yajie FAN
1
;
Wei SONG
1
;
Zhihui YAO
1
;
Miao GE
4
;
Qian WANG
2
;
Congxia WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Healthy population; Hypertension; Trace elements; Systolic blood pressure; Diastolic blood pressure
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2022;43(3):324-330
- CountryChina
- Language:Chinese
- Abstract: 【Objective】 To explore the correlation between serum trace elements and systolic and diastolic blood pressure in healthy population and patients with hypertension. 【Methods】 The health examination data of the subjects from our hospital from September 2018 to May 2021 were selected. They consisted of 3430 healthy people with no history of chronic diseases and 216 patients with hypertension previously diagnosed. We measured the levels of serum zinc, iron, calcium, magnesium, lead, copper and cadmium and analyzed their correlation with systolic blood pressure (SBP) and diastolic blood pressure (DBP). 【Results】 The incidence of low zinc (9.5%) and hypomagnesemia (1.8%) was relatively low, while hypomagnesemia (27.8%) was relatively common in the healthy population. Logistic regression analysis showed that age, BMI and serum albumin were associated with increased SBP and DBP. Fasting blood glucose (OR=1.095, 95% CI: 1.007-1.191) and blood lead (OR=1.006, 95% CI: 1.000-1.012) were risk factors for SBP. Serum total cholesterol (OR=1.244, 95% CI: 1.095-1.412), serum iron (OR=1.275, 95% CI: 1.114-1.460) and blood lead (OR=1.010, 95% CI: 1.004-1.015) were risk factors, while serum magnesium (OR=0.488, 95% CI: 0.266-0.894) acted as a protective factor for DBP. After adjusting for age, gender, BMI, waist-hip ratio, and smoking history, there was no significant difference in serum trace element levels between the hypertension and healthy control groups. 【Conclusion】 SBP is correlated with serum lead, while DBP is positively correlated with serum iron and lead, but negatively correlated with serum magnesium in normal healthy population. There was no significant difference in serum trace element content between hypertensive patients and healthy control group, but the conclusion still needs to be further verified.