Relationship between hypoadiponectinemia and hypertension in young individuals with normal renal function: Hanzhong adolescent hypertension study

Xuanhui Guo; Chao Chu; Qiong MA; Yueyuan Liao; Yu Yan; Yue Yuan; Jiawen HU; Yang Wang; Ruihai Yang; Jianjun MU

Return

Relationship between hypoadiponectinemia and hypertension in young individuals with normal renal function: Hanzhong adolescent hypertension study

VernacularTitle:肾功能正常的青年个体血浆脂联素水平与高血压的关系：汉中青少年高血压队列
Author: Xuanhui GUO ^{1
,

2} ; Chao CHU ¹ ; Qiong MA ¹ ; Yueyuan LIAO ¹ ; Yu YAN ¹ ; Yue YUAN ¹ ; Jiawen HU ¹ ; Yang WANG ¹ ; Ruihai YANG ³ ; Jianjun MU ¹
Author Information

1. Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061
2. Xi’an No. 1 Hospital, Xi’an 710002
3. Cardiovascular Disease Research Institure, Hanzhong People’s Hospital, Hanzhong 723000, China
Publication Type:Journal Article
Keywords: hypoadiponectinemia; hypertension; renal function; adolescent
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2022;43(4):594-599
CountryChina
Language:Chinese
Abstract: 【Objective】 To explore the relationship between plasma adiponectin levels and hypertension based on the Hanzhong adolescent hypertension cohort. 【Methods】 A total of 361 young individuals with normal renal function， aged 32 to 41 years old， were taken as the research subjects. We collected or measured data including general characteristics， blood pressure （BP）， height， weight， pulse rate， and biochemistry indexes such as fasting glucose， blood lipid and plasma hs-CRP. The concentration of plasma adiponectin was determined by ELISA method. Binary logistic regression was performed to analyze the relationship between plasma adiponectin and hypertension. 【Results】 The plasma adiponectin level in patients with hypertension was significantly lower than that in normotensive patients ［3.56 （2.57-5.02）） μg/mL vs. 4.82 （3.19-6.89） μg/mL， P=0.012］. Partial correlation analysis showed a weak correlation of plasma adiponectin level with systolic BP and diastolic BP （r=-0.155， P=0.003 and r=-0.144， P=0.006）. Binary logistic regression analysis showed that after adjusting for confounding factors such as age， BMI， and high-sensitivity C-reactive protein， the risk of hypertension was 2.46 times higher in patients with plasma adiponectin in the lowest gender-specific tertile than those in the highest tertile （OR=2.46， 95% CI: 1.22-4.99）. 【Conclusion】 Hypoaponectinemia is an independent risk factor for hypertension in young individuals with normal renal function.