Efficacy and safety of Jiuhua hemorrhoid suppository plus diosmin for the treatment of hemorrhoid hemorrhage: a multicenter, randomized, and controlled trial
10.1016/j.dcmed.2024.01.009
- Author:
RONG Xinqi
1
;
WU Mingsheng
1
;
XIN Xuezhi
2
;
ZHANG Bo
3
;
LIU Dianwen
4
;
XIAO Huirong
5
;
WANG Zhenyi
6
;
CUI Junhui
7
;
WANG Jianping
8
;
WANG Zhongcheng
9
;
FAN Xiaohua
10
;
HU Ying
1
;
RONG Yisheng
11
;
LI Ying
6
Author Information
1. Department of Proctology, The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China
2. Department of Proctology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China
3. Department of Proctology, Zhongda Hospital Southeast University, Nanjing, Jiangsu 210009, China
4. Department of Proctology, Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450003, China
5. Department of Proctology, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi 330006, China
6. Department of Proctology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
7. Department of Proctology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China
8. Department of Proctology, Lishui Municipal Central Hospital, Lishui, Zhejiang 323020, China
9. Department of Proctology, Chengdu Anorectal Hospital, Chengdu, Sichuan 610017, China
10. Department of Proctology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, China
11. Department of Emergency, The Fourth Hospital of Changsha, Changsha, Hunan 410006, China
- Publication Type:Journal Article
- Keywords:
Hemorrhoidal disease, Anal bleeding, Flavonoids, Jiuhua hemorrhoid suppository, Diosmin, Traditional Chinese medicine, Clinical trial
- From:
Digital Chinese Medicine
2023;6(4):467-476
- CountryChina
- Language:English
-
Abstract:
Objective: To compare the efficacy and safety of combining diosmin with Jiuhua hemorrhoid suppository versus diosmin alone for the treatment of hemorrhoid hemorrhage.
Methods:The Jiuhua hemorrhoid suppository study was conducted in 10 medical centers across China from April 1, 2019 to June 30, 2020. Patients with hemorrhoid bleeding were randomized in a ratio of 1 : 1 to either receive Jiuhua hemorrhoid suppository and diosmin tablets (the study group) or diosmin tablets alone (the control group). The suppository was used once a day after defecation or at bedtime after rinsing the anus with warm water. Diosmin tablets were administered only once a day (0.9 g). The primary endpoint of the study was the assessment of hemorrhoid bleeding relief 7 ± 2 days after treatment, classified as “very effective” “effective” and “ineffective”. The secondary endpoint included the evaluation of pain alleviation using the visual analogue scale (VAS, with scores ranging from 0 to 10) and edema (with scores ranging from 0 to 3). The safety of the two treatment regimens was evaluated 14 ±
2 days after drug administration.
Results:The full analysis set (FAS) comprised 107 participants in the study group and 111 in the control group, while the per-protocol set (PPS) included 106 participants in the study group and 111 in the control group. In terms of hemorrhoid bleeding, the proportion of very effective and effective cases in the study group were significantly higher than that in the control group [106 (99.06%) vs. 91 (81.98%), P < 0.0001] in the FAS, and the PPS results [105 (99.06%) vs. 91 (81.98%), P < 0.0001] were comparable to the FAS results. The pain VAS scores at day 7 after treatment were comparable between the two groups (0.80 ± 1.17 vs. 0.80 ± 1.20, P = 0.2177). The majority of the participants in both groups had an edema score of 0 at day 7 after treatment [96 (89.72%) vs. 99 (91.67%), P = 0.370 5]. Adverse events (AEs) occurred in 9 patients (8.4%) in the study group and 3 patients (2.7%) in the control group. In addition, 5 AEs in the study group and 1 AE in the control group were possibly in association with the study drug.
Conclusion:Compared with the administration of diosmin oral tablets alone, the addition of Jiuhua hemorrhoid suppository to the tablets demonstrates enhanced efficacy in addressing hemorrhoid bleeding, with satisfactory patient adherence and acceptable safety.
- Full text:jiuhua-rongxinqi.pdf
