Research progress on autocrine and paracrine regulation of osteosarcoma cell growth
10.13200/j.cnki.cjb.003880
- VernacularTitle:骨肉瘤细胞生长的自分泌和旁分泌调节的研究进展
- Author:
DU Shaowen
- Publication Type:Journal Article
- Keywords:
Osteosarcoma(OS);
Autocrine;
Paracrine;
Cytokines
- From:
Chinese Journal of Biologicals
2024;37(2):239-244
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma(OS)is one of the most common malignant tumors in bone tissue,and its specific mechanism is not yet fully clear. Studies have shown that OS cells express different cytokines(CKs)and their receptors in the development stage of tumors,and enable them to grow autonomously and confer metastatic ability through autocrine and paracrine effects. In this regard,the most important CKs mainly includes insulin-like growth factor-1,transforming growth factor-β,chemokine 5 and interleukin-8,which can regulate the tumor microenvironment that is conducive to tumor growth,invasion and metastasis. This review summarizes the role and mode of action of CKs and their biological relevance to OS cells,hoping to provide effective new markers and therapeutic targets for clinical treatment of OS.
