Regulating PI3K/Akt Signaling Pathway by Traditional Chinese Medicine to Improve Cognitive Impairment： A Review
10.13422/j.cnki.syfjx.20232141
- VernacularTitle:中药调控PI3K/Akt信号通路改善认知障碍的研究进展
- Author:
Feifei LIU
1
;
Yan ZHONG
1
;
Liping CHEN
2
;
Xiwen CHANG
2
;
Wenbing LI
2
;
Rong WANG
2
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. 940th Hospital， PLA Joint Logistic Support Force， Lanzhou 730050， China
- Publication Type:Journal Article
- Keywords:
phosphatidylinositol 3-kinase （PI3K）-protein kinase B （Akt） signal pathway;
cognitive impairment;
Traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(7):281-289
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment refers to the abnormality of the hippocampus， cortex and other parts of the brain， which is manifested by the decline of cognitive abilities such as learning， memory and attention. With the increase in people's work pressure and bad living habits， the incidence of cognitive impairment is getting higher and higher， which seriously affects people's normal life. However， there are adverse reactions such as gastrointestinal reactions and extrapyramidal reactions in Western drug treatment for cognitive impairment. Therefore， the development of a drug with relatively minimal adverse reactions is of great significance. Traditional Chinese medicine （TCM） has the characteristics of "multi-component， multi-pathway and multi-target"， and the incidence of adverse reactions is relatively low. Studies have shown that the pathogenesis of cognitive impairment is closely related to oxidative stress， inflammation， apoptosis， autophagy and other processes of neurons in the cerebral cortex and hippocampus. Phosphatidylinositol 3-kinase （PI3K）-protein kinase B （Akt） signal pathway plays an important role in the transmission of intracellular and intracellular signals， and in the regulation of cellular inflammation， apoptosis， autophagy， etc. TCM monomers， TCM extracts， and TCM compounds exert anti-inflammatory， antioxidant， anti-apoptotic and autophagy regulation effects by regulating the PI3K/Akt signaling pathway to improve cognitive impairment. This review first summarized the composition and regulatory process of the PI3K/Akt signaling pathway， and then discussed the research progress on the improvement of cognitive impairment through the improvement of oxidative stress， inflammation， apoptosis and autophagy of neurons. Finally， the recent research status of the regulation of this signaling pathway by TCM extracts， TCM monomers and TCM compounds to improve cognitive impairment was summarized. This study provides a theoretical basis for the future study of new TCM related to cognitive impairment.
