Anti-cancer Effect of Traditional Chinese Medicine in Regulating Cellular Senescence： A Review
10.13422/j.cnki.syfjx.20231321
- VernacularTitle:中医药调控细胞衰老发挥抗癌作用的研究进展
- Author:
Shuang ZHAO
1
;
Dong WANG
1
;
Haoyang SHI
1
;
Fangyuan WANG
1
;
Jingyan MENG
1
Author Information
1. Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
- Publication Type:Journal Article
- Keywords:
cell senescence;
cancer;
traditional Chinese medicine;
tumor microenvironment;
cell factor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(7):265-271
- CountryChina
- Language:Chinese
-
Abstract:
In recent years， the incidence and mortality rates of cancer have been increasing， posing a serious threat to human health. Western medicine mainly uses treatments such as surgical resection， chemotherapy， immunotherapy and targeted therapy， but they are prone to complications， drug resistance and adverse reactions. A growing number of studies have shown that traditional Chinese medicine has obvious advantages in the treatment of cancer， reducing the recurrence rate of cancer and improving the quality of survival of patients. Cellular senescence refers to a state of irreversible cell cycle growth arrest when cells cease to proliferate after a limited number of divisions， resulting in a decline in cell proliferation and differentiation capacities and physiological functions， accompanied by morphological changes such as flattening and multinuclear morphology. At the molecular level， it shows increased expression of DNA damage-related genes， reduced expression of cell cycle-related factors and significant secretory activity. The malignant development of cancer is closely related to cellular senescence. With the increasing number of cancer cell proliferation， cancer-related genes undergo continuous mutations， freeing them from cellular senescence and thus achieving unlimited proliferation. Through recent studies， it has been found that induction of tumor cell senescence， possibly through modulation of cellular DNA damage， cell cycle arrest and senescence-associated secretory phenotype （SASP）， which converts the suppressive immune tumor microenvironment to an activated immune tumor microenvironment and thus reverses the escape of tumor cell senescence， is a promising strategy for cancer therapy. However， the mechanism of cellular senescence in cancer progression is not fully understood， especially the anti-cancer role played by traditional Chinese medicine in regulating cellular senescence. This article summarized and concluded the specific molecular mechanisms of cellular senescence， the role of cellular senescence in cancer progression， and the mechanism of anti-cancer effects of traditional Chinese medicine based on cellular senescence from the perspective of regulating cellular senescence， with a view to providing ideas and methods for the anti-cancer effects of traditional Chinese medicine and the development of new drugs.
