Advances in corneal stromal regeneration and repair
10.3980/j.issn.1672-5123.2024.3.10
- VernacularTitle:角膜基质再生与修复的研究进展
- Author:
Tianshuo ZHENG
1
;
Xuejing SHI
1
;
Meng XIN
1
Author Information
1. Department of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264199, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
cornea;
corneal stroma;
regenerative medicine;
cell therapy;
tissue engineering;
gene editing
- From:
International Eye Science
2024;24(3):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Corneal stroma is a significant part of the cornea and plays a significant role in the eye's refractive system. Although corneal transplantation is now the most effective treatment for corneal stromal disease, its advancement has been constrained by a shortage of donors, the need for prolonged immunosuppressive medicine to prevent rejection, and low graft survival rates. An alternate strategy is to use the corneal stroma's natural capacity for regeneration to create the ideal conditions for the collagenous extracellular matrix of the stroma to self-renew. However, it is challenging to replicate the intricate ultrastructure of the corneal stroma in vitro. Regenerative medicine has so been used to address these issues. These approaches refer to numerous disciplines, including stem cell-induced differentiation, tissue engineering and gene editing. This article provides potential directions for the future clinical applications of corneal stromal regeneration and repair while summarizing pertinent techniques, research progress, and issues.
