Role of sex hormones in keratoconus and potential therapeutic targets
10.3980/j.issn.1672-5123.2024.3.08
- VernacularTitle:性激素在圆锥角膜中的作用及潜在治疗靶点
- Author:
Yi YUAN
1
,
2
,
3
;
Liyan XU
1
,
2
,
3
;
Kaili YANG
1
,
2
,
3
;
Shengwei REN
1
,
2
,
3
Author Information
1. People's Hospital of Zhengzhou University
2. Henan Provincial People's Hospital
3. Henan Eye Hospital, Zhengzhou 450003, Henan Province, China
- Publication Type:Journal Article
- Keywords:
keratoconus;
estrogen;
androgen;
progesterone;
prolactin;
gonadotropin
- From:
International Eye Science
2024;24(3):375-379
- CountryChina
- Language:Chinese
-
Abstract:
Keratoconus is a blinding corneal disease characterized by central or paracentral corneal thinning and conical ectasia, and usually happens in adolescence. Currently, the etiology of keratoconus is unclear. Multiple studies have identified an association between genetics, eye rubbing, allergic diseases, ultraviolet exposure and keratoconus. Recently, several studies identified that sex hormones also played important roles in the pathogenesis of keratoconus. The disturbance of sex hormones may increase the risk of occurrence and progress of keratoconus. This review aims to summarize the pathophysiological effects of sex hormones on the cornea, clarify the effects of sex hormones on keratoconus and its related inflammatory or immune mechanisms, and explore the role of sex hormones in the early diagnosis and treatment of keratoconus, providing reference and help for clinical work.
