Research progress of chemotherapy-related diarrhea induced by molecularly targeted anti-tumor drugs
- VernacularTitle:抗肿瘤分子靶向药物致化疗相关性腹泻的研究进展
- Author:
Xuelin SUN
1
;
Li ZHENG
2
;
Hongsheng LI
1
;
Xin HU
1
;
Yatong ZHANG
1
Author Information
1. Dept. of Pharmacy，Beijing Hospital/ National Geriatrics Center/Institute of Geriatrics，Chinese Academy of Medical Science，Beijing 100730，China
2. Dept. of Pharmacy，China Aerospace Science & Industry Corporation 731 Hospital，Beijing 100074，China
- Publication Type:Journal Article
- Keywords:
chemotherapy-related diarrhea;
tumor;
targeted therapy;
intestinal toxicity;
adverse drug reactions
- From:
China Pharmacy
2024;35(4):506-512
- CountryChina
- Language:Chinese
-
Abstract:
Diarrhea caused by chemotherapy is called chemotherapy-related diarrhea （CRD）. CRD can lead to reduced treatment effectiveness and compliance， affect the long-term outcome of tumor patients， and can be life-threatening in severe cases. In addition to conventional chemotherapy drugs， many molecularly targeted drugs are also associated with CRD， including small molecule epidermal growth factor receptor （EGFR） inhibitors， anti-EGFR monoclonal antibodies， phosphoinositide 3-kinase inhibitors， small molecule inhibitors of vascular endothelial growth factor receptor， BCR-ABL1 and KIT inhibitors， human epidermal growth factor receptor 2 target inhibitors， cyclin-dependent protein kinase inhibitors， antibody-drug conjugates and other molecularly targeted drugs. The occurrence mechanism may be related to the intestinal mucosal injury or enteritis caused by molecularly targeted drugs. The clinical manifestations are increased stool frequency and/or loose imposition， and patients are often associated with excess hyperproduction and/or colic. The incidence of CRD varies with different drugs. Great importance should be attached to collecting medical history and differential diagnosis， actively intervening and conducting dynamic evaluation， strengthening patient education， and timely detecting and preventing the occurrence of intestinal toxicity.
