Development of Chinese herbal medicine for sensorineural hearing loss.
10.1016/j.apsb.2023.11.001
- Author:
Yunhao WU
1
;
Jingwen ZHANG
2
;
Qiuping LIU
3
;
Zhuang MIAO
3
;
Renjie CHAI
1
;
Wenyong CHEN
2
Author Information
1. State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China.
2. Department of Otolaryngology-Head and Neck, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.
3. Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Jiangnan University, Wuxi 214000, China.
- Publication Type:Review
- Keywords:
Active ingredients;
Chinese herbal medicine;
Hair cells;
Molecular mechanism;
Noise;
Ototoxic drugs;
Prescriptions;
Sensorineural hearing loss
- From:
Acta Pharmaceutica Sinica B
2024;14(2):455-467
- CountryChina
- Language:English
-
Abstract:
According to the World Health Organization's world report on hearing, nearly 2.5 billion people worldwide will suffer from hearing loss by 2050, which may contribute to a severe impact on individual life quality and national economies. Sensorineural hearing loss (SNHL) occurs commonly as a result of noise exposure, aging, and ototoxic drugs, and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear, which is mainly triggered by reactive oxygen species accumulation, inflammation, and mitochondrial dysfunction. Though recent advances have been made in understanding the ability of cochlear repair and regeneration, there are still no effective therapeutic drugs for SNHL. Chinese herbal medicine which is widely distributed and easily accessible in China has demonstrated a unique curative effect against SNHL with higher safety and lower cost compared with Western medicine. Herein we present trends in research for Chinese herbal medicine for the treatment of SNHL, and elucidate their molecular mechanisms of action, to pave the way for further research and development of novel effective drugs in this field.
