Visualization of nasal powder distribution using biomimetic human nasal cavity model.

Jiawen SU; Yan Liu; Hongyu Sun; Abid Naeem; Huipeng XU; Yue QU; Caifen Wang; Zeru LI; Jianhua LU; Lulu Wang; Xiaofeng Wang; Jie WU; Lixin Sun; Jiwen Zhang; Zhigang Wang; Rui Yang; Li WU

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Visualization of nasal powder distribution using biomimetic human nasal cavity model.

Author: Jiawen SU ¹ ; Yan LIU ² ; Hongyu SUN ³ ; Abid NAEEM ¹ ; Huipeng XU ³ ; Yue QU ² ; Caifen WANG ³ ; Zeru LI ³ ; Jianhua LU ⁴ ; Lulu WANG ⁵ ; Xiaofeng WANG ⁵ ; Jie WU ⁴ ; Lixin SUN ² ; Jiwen ZHANG ¹ ; Zhigang WANG ⁴ ; Rui YANG ² ; Li WU ¹
Author Information

1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
2. Shenyang Pharmaceutical University, Shenyang 110016, China.
3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
4. Nantong Haimen People's Hospital, Nantong 226199, China.
5. National Institutes for Food and Drug Control, Beijing 100000, China.
Publication Type:Journal Article
Keywords: Biomimetic nasal model; Nasal drug delivery; Nasal drug deposition; Nasal drug distribution; Nasal drug distribution visualization; Nasal powder; Three-dimensional printing; Three-dimensional reconstruction
From: Acta Pharmaceutica Sinica B 2024;14(1):392-404
CountryChina
Language:English
Abstract: Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity. However, no reliable method is currently available to assess its impact on delivery performance. In this study, a biomimetic nasal model based on three-dimensional (3D) reconstruction and three-dimensional printing (3DP) technology was developed for visualizing the deposition of drug powders in the nasal cavity. The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females. The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test. The experimental device produced the most satisfactory results with five spray times. Furthermore, particle sizes and spray angles were found to significantly affect the experimental device's performance and alter drug distribution, respectively. Additionally, mometasone furoate (MF) nasal spray (NS) distribution patterns were investigated in a goat nasal cavity model and three male goat noses, confirming the in vitro and in vivo correlation. In conclusion, the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.