The role of bacteria and its derived biomaterials in cancer radiotherapy.
10.1016/j.apsb.2022.10.013
- Author:
Yu ZHANG
1
;
Ruizhe HUANG
1
;
Yunchun JIANG
1
;
Wenhao SHEN
1
;
Hailong PEI
1
;
Guanglin WANG
1
;
Pei PEI
2
;
Kai YANG
1
Author Information
1. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.
2. Teaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
- Publication Type:Review
- Keywords:
Bacteria-based biomaterials;
Bacterial therapy;
Engineered bacteria;
Radiation-activation;
Radio-protector;
Radio-sensitization;
Radiotherapy;
Synergy effect
- From:
Acta Pharmaceutica Sinica B
2023;13(10):4149-4171
- CountryChina
- Language:English
-
Abstract:
Bacteria-mediated anti-tumor therapy has received widespread attention due to its natural tumor-targeting ability and specific immune-activation characteristics. It has made significant progress in breaking the limitations of monotherapy and effectively eradicating tumors, especially when combined with traditional therapy, such as radiotherapy. According to their different biological characteristics, bacteria and their derivatives can not only improve the sensitivity of tumor radiotherapy but also protect normal tissues. Moreover, genetically engineered bacteria and bacteria-based biomaterials have further expanded the scope of their applications in radiotherapy. In this review, we have summarized relevant researches on the application of bacteria and its derivatives in radiotherapy in recent years, expounding that the bacteria, bacterial derivatives and bacteria-based biomaterials can not only directly enhance radiotherapy but also improve the anti-tumor effect by improving the tumor microenvironment (TME) and immune effects. Furthermore, some probiotics can also protect normal tissues and organs such as intestines from radiation via anti-inflammatory, anti-oxidation and apoptosis inhibition. In conclusion, the prospect of bacteria in radiotherapy will be very extensive, but its biological safety and mechanism need to be further evaluated and studied.
