Advancing drug delivery to articular cartilage: From single to multiple strategies.
10.1016/j.apsb.2022.11.021
- Author:
Tianyuan ZHAO
1
,
2
;
Xu LI
3
;
Hao LI
1
,
2
;
Haoyuan DENG
1
,
2
;
Jianwei LI
1
,
2
;
Zhen YANG
1
,
2
;
Songlin HE
1
,
2
;
Shuangpeng JIANG
4
;
Xiang SUI
1
,
2
;
Quanyi GUO
1
,
2
;
Shuyun LIU
1
,
2
Author Information
1. Institute of Orthopedics, The First Medical Center, Chinese PLA General Hospital
2. Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing 100853, China.
3. Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatology, The Chinese University of Hong Kong, 999077, Hong Kong, China.
4. Department of Joint Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
- Publication Type:Review
- Keywords:
Articular cartilage;
Biomaterials;
Cartilage injury;
Cartilage regeneration;
Drug delivery systems;
Multiple drug delivery strategy;
Osteoarthritis;
Therapeutic factors
- From:
Acta Pharmaceutica Sinica B
2023;13(10):4127-4148
- CountryChina
- Language:English
-
Abstract:
Articular cartilage (AC) injuries often lead to cartilage degeneration and may ultimately result in osteoarthritis (OA) due to the limited self-repair ability. To date, numerous intra-articular delivery systems carrying various therapeutic agents have been developed to improve therapeutic localization and retention, optimize controlled drug release profiles and target different pathological processes. Due to the complex and multifactorial characteristics of cartilage injury pathology and heterogeneity of the cartilage structure deposited within a dense matrix, delivery systems loaded with a single therapeutic agent are hindered from reaching multiple targets in a spatiotemporal matched manner and thus fail to mimic the natural processes of biosynthesis, compromising the goal of full cartilage regeneration. Emerging evidence highlights the importance of sequential delivery strategies targeting multiple pathological processes. In this review, we first summarize the current status and progress achieved in single-drug delivery strategies for the treatment of AC diseases. Subsequently, we focus mainly on advances in multiple drug delivery applications, including sequential release formulations targeting various pathological processes, synergistic targeting of the same pathological process, the spatial distribution in multiple tissues, and heterogeneous regeneration. We hope that this review will inspire the rational design of intra-articular drug delivery systems (DDSs) in the future.
