A Soft Tissue Perineurioma and a Hybrid Tumor of Perineurioma and Schwannoma.
10.4132/KoreanJPathol.2012.46.1.75
- Author:
Ji Young PARK
1
;
Nam Jo PARK
;
Sang Pyo KIM
;
Kun Young KWON
;
Sang Sook LEE
Author Information
1. Department of Pathology, Keimyung University School of Medicine, Daegu, Korea. sangsook@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Soft tissue;
Perineurioma;
Nerve sheath neoplasms;
Hybrid tumor
- MeSH:
Basement Membrane;
Chimera;
Cytoplasm;
Humans;
Korea;
Male;
Mediastinum;
Middle Aged;
Mucin-1;
Nerve Sheath Neoplasms;
Neurilemmoma;
Peripheral Nerves;
S100 Proteins;
Skin
- From:Korean Journal of Pathology
2012;46(1):75-78
- CountryRepublic of Korea
- Language:English
-
Abstract:
Perineuriomas are composed of differentiated perineurial cells. Perineuriomas have been recently recognized by the immunoreactivity for epithelial membrane antigen (EMA). Microscopically, perineuriomas show proliferation of spindle cells with wavy nuclei and delicate elongated bipolar cytoplasmic processes. The tumor cells are usually negative for the S-100 protein. Ultrastructurally, perineurial cells reveal slender, nontapered processes containing pinocytic vesicles and discontinuous basal lamina. Interestingly, hybrid tumors of benign peripheral nerve sheath tumor (PNST) have been recently reported by using immunohistochemical and ultrastructural investigations. Herein, we report a case of soft tissue perineurioma arising in the skin of a 56-year-old female; another case of a hybrid tumor of perineurioma and schwannoma in the posterior mediastinum occurred in a 53-year-old male, which is the first case of the hybrid PNST tumor reported in Korea.
