A new class of potent liver injury protective compounds: Structural elucidation, total synthesis and bioactivity study.
10.1016/j.apsb.2023.05.001
- Author:
Kailong JI
1
;
Wei LIU
1
;
Weihang YIN
1
;
Xiangrong KONG
2
;
Honghong XU
1
;
Zeng-Wei LAI
1
;
Jing-Ya LI
1
;
Jian-Min YUE
1
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
2. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
Anti-inflammation;
Liver injury protection;
Phychetins;
Phyllanthus franchetianus;
Structural elucidation;
Total synthesis
- From:
Acta Pharmaceutica Sinica B
2023;13(8):3414-3424
- CountryChina
- Language:English
-
Abstract:
A new class of potent liver injury protective compounds, phychetins A-D ( 1- 4) featuring an unique 6/6/5/6/5 pentacyclic framework, were isolated and structurally characterized from a Chinese medicinal plant Phyllanthus franchetianus. Compounds 2- 4 are three pairs of enantiomers that were initially obtained in a racemic manner, and were further separated by chiral HPLC preparation. Compounds 1- 4 were proposed to be originated biosynthetically from a coexisting lignan via an intramolecular Friedel-Crafts reaction as the key step. A bioinspired total synthesis strategy was thus designated, and allowed the effective syntheses of compounds 2- 4 in high yields. Some of compounds exhibited significant anti-inflammatory activities in vitro via suppressing the production of pro-inflammatory cytokine IL-1β. Notably, compound 4, the most active enantiomeric pair in vitro, displayed prominent potent protecting activity against liver injury at a low dose of 3 mg/kg in mice, which could serve as a promising lead for the development of acute liver injury therapeutic agent.
