Plant-derived nanovesicles: Further exploration of biomedical function and application potential.
10.1016/j.apsb.2022.12.022
- Author:
Aixue LI
1
;
Dan LI
2
;
Yongwei GU
2
;
Rongmei LIU
1
;
Xiaomeng TANG
2
;
Yunan ZHAO
2
;
Fu QI
1
;
Jifu WEI
3
;
Jiyong LIU
1
Author Information
1. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
2. Department of Pharmacy, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
3. Department of Pharmacy, Jiangsu Cancer Hospital, Nanjing 210009, China.
- Publication Type:Review
- Keywords:
Clinical application;
Drug delivery systems;
Extracellular vesicles;
Plant-derived nanovesicles;
Therapeutic agents
- From:
Acta Pharmaceutica Sinica B
2023;13(8):3300-3320
- CountryChina
- Language:English
-
Abstract:
Extracellular vesicles (EVs) are phospholipid bilayer vesicles actively secreted by cells, that contain a variety of functional nucleic acids, proteins, and lipids, and are important mediums of intercellular communication. Based on their natural properties, EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery carriers. Among them, plant-derived nanovesicles (PNVs) are characterized as natural disease therapeutics with many advantages such as simplicity, safety, eco-friendliness, low cost, and low toxicity due to their abundant resources, large yield, and low risk of immunogenicity in vivo. This review systematically introduces the biogenesis, isolation methods, physical characterization, and components of PNVs, and describes their administration and cellular uptake as therapeutic agents. We highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers, including anti-inflammatory, anticancer, wound healing, regeneration, and antiaging properties as well as their potential use in the treatment of liver disease and COVID-19. Finally, the toxicity and immunogenicity, the current clinical application, and the possible challenges in the future development of PNVs were analyzed. We expect the functions of PNVs to be further explored to promote clinical translation, thereby facilitating the development of a new framework for the treatment of human diseases.
